2026-10-11T22:08:57Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33973744 2026-09-23T14:31:37Z category_393 portal_316 item_type_3 month_year_09_2026

Table 1_Longitudinal co-variation of radiographic chest-wall thickness and transcutaneous–arterial CO₂ discrepancy in congenital diaphragmatic hernia: a single-patient case study.pdf Tomonori Kurimoto (22363567) Eiji Hirakawa (22363573) Hiroshi Ohashi (3457490) Takuya Tokuhisa (20808007) Foetal Development and Medicine congenital diaphragmatic hernia measurement discrepancy neonates radiographic chest-wall thickness transcutaneous CO2 Background<p>Transcutaneous carbon dioxide (tcPCO₂) monitoring enables continuous non-invasive assessment of ventilation in neonates, but local tissue conditions may contribute to disagreement between tcPCO₂ and arterial PaCO₂ measurements. We explored within-patient temporal co-variation among radiographic chest-wall thickness, sensor heating power, and the discrepancy between tcPCO₂ and arterial PaCO₂ in a critically ill neonate.</p>Methods<p>We conducted an exploratory single-patient longitudinal case study over 28 days. Serial measurements of tcPCO₂, arterial PaCO₂, radiographic chest-wall thickness ratio (%skin), an unvalidated radiographic measure explored as a potential surrogate of tissue edema, sensor heating power, and daily fluid balance were evaluated. Both the signed difference (tcPCO₂−PaCO₂) and absolute difference |tcPCO₂−PaCO₂| were summarized descriptively. Temporal trajectories and within-patient associations were explored with attention to serial dependence and shared time trends.</p>Results<p>Increasing radiographic chest-wall thickness coincided with greater tcPCO₂–PaCO₂ discrepancy and higher sensor heating power. The three variables showed broadly similar rise-and-fall temporal trajectories. Unadjusted within-patient correlations were strong (r = 0.766–0.813), and residual correlations persisted but were attenuated after removal of the quadratic Day/Day² trend (residual r = 0.545–0.625). These residual correlations were interpreted descriptively and not as evidence of a time-independent relationship. PCA identified a dominant principal component explaining 85.9% of total variance, descriptively summarizing shared temporal covariance among radiographic chest-wall thickness, sensor heating power, and tcPCO₂–PaCO₂ discrepancy.</p>Conclusion<p>In this single-patient longitudinal case study, radiographic chest-wall thickness, sensor heating power, and tcPCO₂–PaCO₂ discrepancy showed parallel temporal changes. These findings generate the hypothesis that changes in local tissue conditions associated with increased radiographic chest-wall thickness may contribute to tcPCO₂–PaCO₂ disagreement, but causal inference is not possible and validation in multi-patient studies is required.</p> 2026-09-23T14:31:37Z Dataset Dataset 10.3389/fped.2026.1887546.s001 https://figshare.com/articles/dataset/Table_1_Longitudinal_co-variation_of_radiographic_chest-wall_thickness_and_transcutaneous_arterial_CO_discrepancy_in_congenital_diaphragmatic_hernia_a_single-patient_case_study_pdf/33973744 CC BY 4.0