2026-10-07T18:51:16Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33972832 2026-09-23T11:28:24Z category_398 category_399 category_400 category_401 category_402 category_19 category_403 category_404 portal_316 item_type_3 month_year_09_2026

Table2_Long Non-Coding RNA NR-133666 Promotes the Proliferation and Migration of Fibroblast-Like Synoviocytes Through Regulating the miR-133c/MAPK1 Axis.DOCX Nanwen Zhang (1502857) Ningning Zheng (3916796) Dunxiong Luo (12331775) Duoduo Lin (12331778) Wenzhong Que (12331781) He Wang (250350) Qiuping Huang (9464348) Juhua Yang (45617) Jian Ye (19265) Xiaole Chen (4907794) Basic Pharmacology Clinical Pharmacology and Therapeutics Clinical Pharmacy and Pharmacy Practice Pharmaceutical Sciences Pharmacogenomics Pharmacology Toxicology (incl. Clinical Toxicology) Pharmacology and Pharmaceutical Sciences not elsewhere classified long non-coding RNA (lncRNA) messenger RNA (mRNA) fibroblast-like synoviocytes (FLSs) mitogen-activated protein kinase 1 (MAPK1) rheumatoid arthritis (RA) <p>Long non-coding RNA (lncRNA) is involved in the regulation of rheumatoid arthritis (RA) and many other diseases. In this study, a new lncRNA, NR-133666, was identified to be highly expressed in the adjuvant-induced arthritis rat model using the Agilent lncRNA microarray assay. qRT-PCR verified that NR-133666 was upregulated in fibroblast-like synoviocyte of a collagen-induced arthritis (CIA) rat model. Fluorescence in situ hybridization analysis showed that NR-133666 is mainly expressed in the cytoplasm of collagen-induced arthritis FLS. MTT assay and EdU staining results showed that the proliferation of CIA FLS was inhibited after NR-133666 was knocked down, and the wound healing assay showed that the migration of CIA FLS was also suppressed. Dual luciferase detection was used to confirm the relationship among NR-133666, miR-133c and MAPK1. MAPK1 is the target gene of miR-133c, where NR-133666 acts as a sponge of miR-133c to reduce the inhibitory effect of miR-133c on MAPK1. Overexpression of NR-133666 and MAPK1 can promote the proliferation and migration of CIA FLS, and overexpression of miR-133c can reverse this phenomenon. Western blot indicated that it may be related to the ERK/MAPK signaling pathway. Collectively, we identified that lncRNA NR-133666 acted as a miR-133c sponge that can promote the proliferation and migration of CIA FLS through regulating the miR-133c/MAPK1 axis.</p> 2026-09-23T11:28:24Z Dataset Dataset 10.3389/fphar.2022.887330.s002 https://figshare.com/articles/dataset/Table2_Long_Non-Coding_RNA_NR-133666_Promotes_the_Proliferation_and_Migration_of_Fibroblast-Like_Synoviocytes_Through_Regulating_the_miR-133c_MAPK1_Axis_DOCX/33972832 CC BY 4.0