2026-10-12T05:28:35Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33972670 2026-09-30T00:18:58Z category_26299 portal_12 item_type_5 month_year_09_2026

Jianhua Wu: Right-ventricular dysfunction in congenital heart disease Jianhua Wu (22185565) Biomedical engineering not elsewhere classified congenital heart disease right heart mechanoenergetics crossbridge cycling computational modelling <p dir="ltr">Congenital heart disease (CHD) refers to a range of structural abnormalities of the heart and great vessels due to malformed fetal development. The right ventricle (RV) plays an important role in the development of CHDs, and heart failure due to RV dysfunction is a major cause of morbidity in CHD patients. Despite the high prevalence and high mortality, the mechanisms underlying long-term cardiac dysfunction, especially the RV pathophysiology, are still poorly understood. Therefore, this study aims to investigate the structural, mechanical, and energetic properties of cardiac tissues from patients with CHD. To assess the RV changes in CHD, multi-scale experiments will be conducted, including work-loop calorimetry, mechanometry, confocal microscopy, and mass spectrometry. Complementing these experimental studies, a CHD patient-specific model of cross-bridge function will be developed and parameterised using experimental measurements. We hope to better understand the mechanisms of CHD pathology development and identify potential treatment strategies for CHD patients.</p> 2026-09-30T00:18:58Z Image Poster 10.17608/k6.auckland.33972670.v2 https://figshare.com/articles/poster/Right-ventricular_dysfunction_in_congenital_heart_disease/33972670 CC BY 4.0