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oai:figshare.com:article/33971179 2026-09-23T05:50:30Z category_363 portal_316 item_type_3 month_year_09_2026

Supplementary file 1_Migraine and the risk of glaucoma: a systematic review and meta-analysis.docx Sibiao Lu (25094557) Xiaojing Ye (32898) Sitong Chen (170590) Jisheng Zhang (227247) Tianyi Sun (10874894) Xianming Lin (13952247) Neurology and Neuromuscular Diseases glaucoma meta-analysis migraine risk systematic review Background<p>Migraine and glaucoma are prevalent and burdensome conditions worldwide, yet the evidence linking them remains inconsistent. This systematic review and meta-analysis aimed to synthesize available evidence on their association and investigate sources of heterogeneity.</p>Methods<p>We comprehensively searched PubMed, Embase, and the Cochrane Library from inception to April 8, 2026, for cohort, case–control, and cross-sectional studies examining the migraine-glaucoma link. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models. Heterogeneity was explored via subgroup, sensitivity, and meta-regression analyses. Study quality was assessed using the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality checklist. Publication bias was evaluated via funnel plots, Egger’s test, and trim-and-fill analysis.</p>Results<p>Nineteen studies involving 3,625,071 participants were incorporated. The pooled analysis demonstrated a significant positive association between migraine and glaucoma risk (OR = 1.28, 95% CI: 1.20–1.37), with moderate heterogeneity (I² = 46.2%). Subgroup analyses indicated stronger associations in studies from America, clinic-based settings, those using self-reported migraine diagnosis and those with higher female participant proportions (≥60%). Egger’s test suggested potential publication bias. Following trim-and-fill adjustment (imputing eight potentially missing studies), the pooled estimate remained significant though slightly attenuated (OR = 1.23, 95% CI: 1.13–1.34).</p>Conclusion<p>This meta-analysis suggests migraine is associated with a significantly increased risk of glaucoma. While the association persisted directionally after adjusting for potential publication bias, its magnitude varied by data source, diagnostic method, and population characteristics. Further high-quality prospective studies employing standardized criteria are needed to elucidate causality and underlying mechanisms.</p>Systematic review registration<p>https://www.crd.york.ac.uk/PROSPERO/view/CRD420261367870, CRD420261367870.</p> 2026-09-23T05:50:30Z Dataset Dataset 10.3389/fneur.2026.1890818.s001 https://figshare.com/articles/dataset/Supplementary_file_1_Migraine_and_the_risk_of_glaucoma_a_systematic_review_and_meta-analysis_docx/33971179 CC BY 4.0