2026-10-13T08:50:26Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33970821 2026-09-23T05:08:46Z category_4 category_7 category_12 category_13 category_14 category_272 category_46 category_734 category_811 category_64 category_128 category_132 portal_63 item_type_3 month_year_09_2026

Maternal Epigenetic Signatures Linking Prenatal Serum PFAS Concentrations to Birth Size in an African American Maternal–Child Cohort Youran Tan (16911415) Anne L. Dunlop (4682503) Todd M. Everson (4114162) Alicia K. Smith (8578314) Stephanie M. Eick (8374818) Ziyin Tang (11997959) Shudi Pan (20780168) Neha Sehgal (326548) Dana Boyd Barr (207320) Kurunthachalam Kannan (487986) P. Barry Ryan (12224) Carmen J. Marsit (109106) Donghai Liang (5770817) Biochemistry Medicine Cell Biology Genetics Molecular Biology Environmental Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Cancer Hematology Infectious Diseases maternal dna methylation exploratory mediation analyses dna methylation profiling blood mononuclear cell reduced birth size infant birth size birth size indicators serum pfas assessment least one pfas specific birth weight birth size z </ wdyhv1 </ six cpgs quantile g polyfluoroalkyl substance pfas levels lipid homeostasis largest effects inflammatory response immune activity >- scores 132 cpgs Per- and polyfluoroalkyl substance (PFAS) exposures have been linked to reduced birth size, but the underlying epigenetic mechanisms remain unclear. Among 296 mother–infant dyads in the Atlanta African American Maternal–Child Cohort (2016–2020), early pregnancy maternal blood samples (8–14 weeks) were processed for serum PFAS assessment and blood mononuclear cell (PBMC) DNA methylation profiling. We assessed birth size using sex-specific birth weight <i>z</i>-scores (BWZ) and small-for-gestational-age (SGA) status. Individual and mixture PFAS methylation associations were estimated by using robust generalized linear regression and quantile g-computation. We also conducted differentially methylated region (DMR), gene ontology, sex-specific, and exploratory mediation analyses. Overall, 132 CpGs were associated with at least one PFAS (FDR < 0.05), including 34, 60, 32, and 10 linked with PFHxS, PFOS, PFOA, and PFNA, respectively. PFOS showed the largest effects and appeared to drive the mixture associations. Six CpGs (annotated to <i>EVA1A, FCRL1, CTIF, ABHD12, and WDYHV1</i>) were associated with PFAS levels and birth size indicators. We identified 2–9 DMRs associated with individual PFASs and their mixture. Sex-specific PFAS methylation associations were observed. The PFAS-associated genes are involved in the inflammatory response, immune activity, and lipid homeostasis. Prenatal serum PFAS concentrations were associated with alterations in maternal DNA methylation, which in turn were associated with infant birth size. 2026-09-23T00:00:00Z Dataset Dataset 10.1021/acs.est.6c03113.s001 https://figshare.com/articles/dataset/Maternal_Epigenetic_Signatures_Linking_Prenatal_Serum_PFAS_Concentrations_to_Birth_Size_in_an_African_American_Maternal_Child_Cohort/33970821 CC BY-NC 4.0