2026-10-13T06:09:47Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33970465 2026-09-23T04:42:42Z category_388 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_NONO modulates tumorigenesis and metastatic potential of lung squamous cell carcinoma.pdf Jinlong Huang (7060856) Liping Zhu (25704) Weiqing Zhang (582593) Dongliang Lin (10153526) Luoyu Lian (25094044) Wenshan Hong (284664) Zhendong Xu (658079) Zhoujie Ye (15258920) Oncology and Carcinogenesis not elsewhere classified apoptosis cancer cell proliferation LUSC NONO <p>Lung squamous cell carcinoma (LUSC) is associated with limited therapeutic options and poor clinical prognosis. The Octamer nucleotide--binding transcription factor (NONO), which lacks the POU domain, is implicated in nearly every aspect of gene regulation. It participates in various biological processes including cell proliferation, apoptosis, migration, and DNA damage repair. In this study, we report elevated expression of the NONO gene in LUSC as identified through tumor databases. Our biological function experiments confirmed that NONO promotes the proliferation of LUSC cells by inhibiting apoptosis and enhances the tumor cells’ capabilities for invasion and metastasis. Through the mediation of the PI3K/AKT signaling pathway, NONO regulates downstream molecules such as FOXO1 and GSK3β, which are related to cell proliferation and apoptosis. It participates in the regulation of LUSC cell proliferation, invasion and metastasis, and can serve as a potential clinical target for LUSC, providing ideas for exploring new treatment methods.</p> 2026-09-23T04:42:42Z Dataset Dataset 10.3389/fonc.2026.1574103.s001 https://figshare.com/articles/dataset/Data_Sheet_1_NONO_modulates_tumorigenesis_and_metastatic_potential_of_lung_squamous_cell_carcinoma_pdf/33970465 CC BY 4.0