2026-10-12T11:46:19Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33970390 2026-09-23T04:42:39Z category_374 portal_316 item_type_3 month_year_09_2026

Supplementary file 1_A systematic review and meta-analysis of phospholipids in human milk.docx Huanzhe Dong (25093945) Menglu Li (4458208) Yuling Xue (25093948) Shijie Wang (381700) Nan Wang (21935) Benheng Guo (25093951) Yiping Xun (730351) Clinical and Sports Nutrition composition human milk lactation stage phospholipid systematic review Background<p>Phospholipids are important bioactive components in human milk. They are rich in unsaturated fatty acids and play crucial roles in cell signal transduction and infant intellectual development.</p>Methods<p>This study quantitatively pooled concentrations of total phospholipids and their subclasses in human milk, and narratively summarized phospholipid subclass proportions across different countries. Relevant studies published up to October 2025 were searched from six databases. After systematic search, a total of 25 studies were finally included, among which 18 studies on phospholipid concentrations were subjected to meta-analysis.</p>Results<p>Results from the random-effects model showed that the total phospholipid concentration was 251.60 mg/L (175.62, 327.58) in colostrum, 234.71 mg/L (171.07, 298.35) in transitional milk, 197.00 mg/L (166.08, 227.93) in mature milk. Throughout lactation, PC, SM, and PE are the major phospholipid classes in human milk. Subgroup meta-analyses indicated that detection methods were a significant effect for total phospholipids, PE, and PI concentrations within mature milk.</p>Conclusion<p>This systematic review provides updated estimates of phospholipids and their subclasses concentrations in term human milk, and provides a theoretical basis for the application of phospholipids in infant formula.</p>Systematic review registration<p>https://www.crd.york.ac.uk/prospero/, Identiffer CRD420261445346.</p> 2026-09-23T04:42:39Z Dataset Dataset 10.3389/fnut.2026.1929517.s001 https://figshare.com/articles/dataset/Supplementary_file_1_A_systematic_review_and_meta-analysis_of_phospholipids_in_human_milk_docx/33970390 CC BY 4.0