2026-10-06T22:07:28Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33968863 2026-09-28T17:11:31Z category_32963 category_31208 category_33341 category_33038 category_33053 portal_935 item_type_3 month_year_09_2026

Dataset associated with "Water-and energy-efficient dialysate flow optimisation in haemodialysis using a data-driven porous media model" Ruhit Sinha (10624829) Anne Staples (10599341) Engineering Biomedical and clinical sciences Computational methods in fluid flow, heat and mass transfer (incl. computational fluid dynamics) Medical devices Chemical engineering Navier-Stokes simulations Porous media models modified Ergun equation Haemodialyser Dialysate flow optimisation <p dir="ltr">Haemodialysis imposes a substantial environmental burden through high dialysate-water use and the hydraulic energy required to circulate blood and dialysate. Here we develop a porous media framework that couples a data-driven modified Ergun equation for dialysate-side pressure loss with solute transport modelling. We use this framework to introduce clearance per pumping power (CPP), a performance metric that quantifies solute removal per unit hydraulic pumping power. For a modelled PHYLTER® HF 17SD dialyser,<i> </i>CPP is maximised at dialysate-to-blood flow ratios of approximately 1.1 to 0.7, depending on solute and ultrafiltration rate. At a blood flow rate of 300 mL min^-1 and an ultrafiltration rate of 30 mL min^-1, the model predicts that reducing the dialysate flow rate from a typical value of 500 to 280 mL min^-1 would save 48 L of water per session while retaining 93% of the urea clearance; furthermore, maintaining equivalent urea dialysis adequacy (Kt/V) would require only approximately 18 additional minutes in a 4-hour session. These results establish a mechanics-based framework for evaluating clearance-pumping energy tradeoffs in hollow-fibre membrane modules and could support future device- and patient-specific dialysis strategies after clinical validation. This framework may also be adapted to other hollow-fibre systems which are widely used in water treatment, desalination, and medical devices, such as extracorporeal membrane oxygenators and bio-artificial pancreases.</p> 2026-09-28T17:11:31Z Dataset Dataset 10.7294/33968863.v1 https://figshare.com/articles/dataset/Dataset_associated_with_Water-and_energy-efficient_dialysate_flow_optimisation_in_haemodialysis_using_a_data-driven_porous_media_model_/33968863 CC0 1.0 Universal (CC0 1.0) Public Domain Dedication