2026-10-12T12:33:20Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33968659 2026-09-22T19:20:53Z category_4 category_7 category_8 category_19 category_272 category_873 category_39 category_46 category_734 category_132 category_134 portal_87 item_type_3 month_year_09_2026

New bianthrone-type dimeric derivatives isolated from a mangrove-derived fungus <i>Hamigera paravellanea</i> GXIMD 03119 Ya-Qi Chen (22896918) Cai-Qiong Zhu (19691417) Pei Cao (684902) Guang-Ying Chen (670978) Xiang-Xi Yi (17609566) Cheng-Hai Gao (6814535) Yong-Hong Liu (4745961) Kai Liu (159026) Meng Bai (2615941) Biochemistry Medicine Microbiology Pharmacology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Ecology Immunology Biological Sciences not elsewhere classified Infectious Diseases Virology Mangrove endophytic fungus Hamigera paravellanea secondary metabolites antibacterial activity <p>Chemical investigation of the mangrove-derived fungus <i>Hamigera paravellanea</i> GXIMD 03119 afforded two previously undescribed bianthrone-type dimers, emodin bianthrone C (<b>1</b>) and emodin bianthrone D (<b>2</b>), together with three known metabolites (<b>3</b>-<b>5</b>). The structures of two new compounds were established through detailed analysis of NMR spectroscopic data and HRESIMS evidence. The isolated compounds were evaluated for antibacterial activity, and compounds <b>1</b> and <b>2</b> inhibited <i>Staphylococcus aureus,</i> each with an MIC value of 7.81 μg/mL. These results add new members to the emodin bianthrone family and further support mangrove-associated fungi as productive sources of bioactive secondary metabolites.</p> 2026-09-22T19:20:53Z Dataset Dataset 10.6084/m9.figshare.33968659.v1 https://figshare.com/articles/dataset/New_bianthrone-type_dimeric_derivatives_isolated_from_a_mangrove-derived_fungus_i_Hamigera_paravellanea_i_GXIMD_03119/33968659 CC BY 4.0