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        <datestamp>2026-09-22T17:38:52Z</datestamp>
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          <dc:title>&lt;p&gt;Visualisation of the simulations corresponding to Fig 5A and 5B, showing the effect of an autoattractant on the migration of slow-moving cells that break down autoattractant.&lt;/p&gt;</dc:title>
          <dc:creator>David M. Versluis (23672270)</dc:creator>
          <dc:creator>Robert H. Insall (9199791)</dc:creator>
          <dc:subject>Biophysics</dc:subject>
          <dc:subject>Physical Sciences not elsewhere classified</dc:subject>
          <dc:subject>Cell Biology</dc:subject>
          <dc:subject>Molecular Biology</dc:subject>
          <dc:subject>Neuroscience</dc:subject>
          <dc:subject>Biotechnology</dc:subject>
          <dc:subject>Ecology</dc:subject>
          <dc:subject>Immunology</dc:subject>
          <dc:subject>Developmental Biology</dc:subject>
          <dc:subject>Cancer</dc:subject>
          <dc:subject>yet remarkably independent</dc:subject>
          <dc:subject>secondary signalling layer</dc:subject>
          <dc:subject>remain poorly understood</dc:subject>
          <dc:subject>inherent instability rather</dc:subject>
          <dc:subject>inherent chemical instability</dc:subject>
          <dc:subject>excessive signalling drives</dc:subject>
          <dc:subject>optimal lifetimes exist</dc:subject>
          <dc:subject>limit collective migration</dc:subject>
          <dc:subject>directional information cells</dc:subject>
          <dc:subject>primary attractant concentration</dc:subject>
          <dc:subject>based computational model</dc:subject>
          <dc:subject>autoattractants whose removal</dc:subject>
          <dc:subject>autoattractants shape migration</dc:subject>
          <dc:subject>primary attractant</dc:subject>
          <dc:subject>longer lifetimes</dc:subject>
          <dc:subject>collective chemotaxis</dc:subject>
          <dc:subject>immune cells</dc:subject>
          <dc:subject>disperse cells</dc:subject>
          <dc:subject>trigger aggregation</dc:subject>
          <dc:subject>sufficiently short</dc:subject>
          <dc:subject>overall effect</dc:subject>
          <dc:subject>moving aggregates</dc:subject>
          <dc:subject>mediated breakdown</dc:subject>
          <dc:subject>hybrid agent</dc:subject>
          <dc:subject>evolution either</dc:subject>
          <dc:subject>enzymatic breakdown</dc:subject>
          <dc:subject>critical boundary</dc:subject>
          <dc:subject>cellular uptake</dc:subject>
          <dc:subject>autoattractants create</dc:subject>
          <dc:subject>also attracted</dc:subject>
          <dc:subject>accumulation degrades</dc:subject>
          <dc:description>&lt;p&gt;Visualisation of the simulations corresponding to &lt;a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014809#pcbi.1014809.g005" target="_blank"&gt;Fig 5A&lt;/a&gt; and &lt;a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014809#pcbi.1014809.g005" target="_blank"&gt;5B&lt;/a&gt;, showing the effect of an autoattractant on the migration of slow-moving cells that break down autoattractant.&lt;/p&gt;</dc:description>
          <dc:date>2026-09-22T17:56:13Z</dc:date>
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          <dc:identifier>10.1371/journal.pcbi.1014809.s008</dc:identifier>
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