2026-10-11T01:02:19Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33966671 2026-09-22T17:22:40Z category_7 category_12 category_21 category_811 category_64 portal_5 item_type_3 month_year_09_2026

<p>Comparison across Vitamin D thresholds.</p> Kimbley Asaso Omwodo (17457579) Joy Njoki Kimani (25091069) Kuboi Nicodemus (25091072) David Mbugua Kioko (25091075) Antoniya Georgieva (12247778) Medicine Cell Biology Biotechnology Mathematical Sciences not elsewhere classified Cancer interquartile range 47 84 – 34 4 – 99 sufficient (&# 8805 context &# 8209 suboptimal (& lt median serum 25 maternal serum 25 8 – 84 09 – 1 maternal serum vitamin preeclampsia cases compared &# 8805 serum 25 xlink "> specific data significantly lower referral hospital preventive intervention potential value odds ratios moi teaching higher odds findings support confidence intervals antenatal screening 7 ); 006 ). 002 ). 001 ]. <div> <p>Background</p><p>Preeclampsia accounts for about one in five direct maternal deaths in Kenya. Low vitamin D levels have been linked to its pathophysiology. Despite this, context‑specific data from African populations remain limited. The study aimed to determine the association between maternal serum 25-hydroxyvitamin D [25(OH)D] concentrations (nmol/L) in pregnancy and the risk of preeclampsia in a Kenyan population.</p> <p>Methods</p><p>A matched case-control study was conducted at Moi Teaching and Referral Hospital, Kenya. A total of 118 women with confirmed viable intrauterine pregnancies at ≥28 weeks’ gestation were analysed. Fifty-nine women with preeclampsia (cases) and 59 controls were matched by parity, gestation, and age. Serum 25(OH)D was quantified. Vitamin D status was categorised as suboptimal (<50 nmol/L) or sufficient (≥50 nmol/L) status. The association between vitamin D status and preeclampsia was assessed using conditional logistic regression. Odds ratios (ORs) with 95% confidence intervals (CIs) were presented.</p> <p>Results</p><p>Median serum 25(OH)D was significantly lower in preeclampsia cases compared with controls [67.1 nmol/L (interquartile range 47.8–84.0) vs. 77.6 nmol/L (62.4–99.7); <i>P</i> = 0.001]. Suboptimal vitamin D levels (<50 nmol/L) were observed in 32.2% of preeclampsia cases versus 6.8% of controls (<i>P</i> = 0.002). In conditional logistic regression accounting for matching, women with suboptimal vitamin D had higher odds of preeclampsia (OR 8.0; 95% CI: 1.84–34.78; <i>P</i> = 0.006). Each 10 nmol/L decrease in serum 25(OH)D was associated with a 29% increase in preeclampsia odds (OR 1.29; 95% CI: 1.09–1.54; <i>P</i> = 0.004).</p> <p>Conclusions</p><p>In this study, suboptimal maternal serum vitamin D status demonstrated a significant association with preeclampsia. There is potential value in antenatal screening for vitamin D status. Findings support further research into vitamin D supplementation as a preventive intervention for preeclampsia.</p> <p>Trial registration</p><p>Pan African Clinical Trial Registry (<a href="https://clinicaltrials.gov/ct2/show/PACTR202505516303679" target="_blank">PACTR202505516303679</a>).</p></div> 2026-09-22T17:22:30Z Dataset Dataset 10.1371/journal.pone.0358781.t003 https://figshare.com/articles/dataset/_p_Comparison_across_Vitamin_D_thresholds_p_/33966671 CC BY 4.0