2026-10-12T17:01:58Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33962254 2026-09-22T05:40:44Z category_427 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Accelerometer-measured physical activity and risk of incident ulcerative colitis: a population-based prospective study.docx Zitong Li (3245613) Haoran Ke (11503957) Hanxiao Feng (10976410) Qianyun Lin (5132075) Ye Chen (241426) Public Health and Health Services not elsewhere classified accelerometer IBD physical activity primary prevention ulcerative colitis Background<p>Ulcerative colitis (UC) lacks established primary prevention strategies despite its economic burden. Physical activity (PA) is promising, yet studies using self-reported data show inconsistent results. We examined the association between accelerometer-measured physical activity and UC risk in a large prospective cohort.</p>Methods<p>This cohort study analyzed data from 95,197 UK Biobank participants without baseline inflammatory bowel disease and with valid accelerometer data, with follow-up from 2013 to 2015 through 2023. Machine learning models estimated time spent in sedentary behavior, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA). MVPA patterns were categorized as active weekend warriors (≥231.5 min/week, ≥50% in 1–2 days), active regular (≥231.5 min/week, not meeting weekend warrior criteria), and inactive (<231.5 min/week). Cox proportional hazards regression assessed associations between PA and UC risk.</p>Results<p>Over 8.86 years median follow-up, 247 incident UC cases were recorded. MVPA showed a dose–response relationship with UC risk (trend p = 0.004). Compared to the lowest MVPA quartile, the third (231.5 to <402.3 min/week) and highest (>402.3 min/week) quartiles showed multivariable adjusted hazard ratios (aHRs) of 0.59 and 0.63 (95% CI: 0.40–0.85 and 0.43–0.91). Neither LPA nor sedentary time showed significant associations with UC risk. Both weekend warrior (aHR: 0.72, 95% CI: 0.53–0.99) and regular MVPA patterns (aHR: 0.57, 95% CI: 0.39–0.82) correlated with reduced UC risk. These associations remained robust across various subgroups and sensitivity analyses.</p>Conclusion<p>Accelerometer-measured MVPA is associated with reduced UC risk. Both weekend warrior and regular MVPA patterns conferred protection, suggesting that flexibility in exercise scheduling may be feasible.</p> 2026-09-22T05:40:44Z Dataset Dataset 10.3389/fpubh.2026.1955306 https://figshare.com/articles/dataset/Data_Sheet_1_Accelerometer-measured_physical_activity_and_risk_of_incident_ulcerative_colitis_a_population-based_prospective_study_docx/33962254 CC BY 4.0