2026-10-12T04:32:41Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33962182 2026-09-22T05:38:40Z category_374 portal_316 item_type_3 month_year_09_2026

Table 1_Effects of soy and isoflavone interventions on plasma lipid profiles in postmenopausal women: an umbrella review.docx Jia-He Guo (25087963) Zi-Jian Lin (25087966) Yue Li (102191) Shuang Zhang (117657) Ming-Li Sun (10262957) Lu-Jie Fan (25087969) Aykede Abdurazzak (25087972) Lian-Kai Wang (25087975) Yuan Gao (159945) Ya-Juan Kong (25087978) Jia-Ning Jiang (25087990) Zeng Wang (453163) Ling-Ling Wang (1641022) Yi-Ning Li (13265337) Clinical and Sports Nutrition lipid profile postmenopausal women randomized controlled trial soy isoflavones umbrella review Background<p>Although numerous meta-analyses have investigated the effects of soy and isoflavones on lipid profiles in postmenopausal women, a comprehensive evaluation of this evidence remains lacking. This umbrella review synthesized existing meta-analyses of randomized controlled trials to assess the certainty of the evidence.</p>Methods<p>We searched PubMed, Web of Science, Embase, and the Cochrane Database for studies published through April 22, 2026. Methodological quality was evaluated using AMSTAR-2, and evidence certainty was assessed using the GRADE approach.</p>Results<p>Seven meta-analyses comprising 21 associations were included. According to AMSTAR-2, two meta-analyses (29%) demonstrated moderate or high quality. Eighteen associations were supported by evidence of moderate or high certainty according to GRADE. Soy protein containing isoflavones and soy isoflavone extracts significantly reduced total cholesterol (MD = −0.12 mmol/L, 95% CI: −0.21 to −0.03). Soy isoflavones reduced low-density lipoprotein cholesterol (SMD = −0.11, 95% CI: −0.21 to −0.01). Furthermore, unfermented soy products significantly increased high-density lipoprotein cholesterol (MD = 0.06 mmol/L, 95% CI: 0.02 to 0.10).</p>Conclusion<p>Specific soy-based interventions, rather than general soy consumption, were associated with beneficial changes in lipid profiles among postmenopausal women.</p>Systematic review registration<p>CRD420251243075.</p> 2026-09-22T05:38:40Z Dataset Dataset 10.3389/fnut.2026.1949200.s001 https://figshare.com/articles/dataset/Table_1_Effects_of_soy_and_isoflavone_interventions_on_plasma_lipid_profiles_in_postmenopausal_women_an_umbrella_review_docx/33962182 CC BY 4.0