2026-10-14T03:12:33Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33961912 2026-09-22T05:30:12Z category_658 portal_316 item_type_3 month_year_09_2026

Supplementary file 2_Exercise-responsive endocrine-metabolic mediators in diabetes and cardiometabolic disorders: a systematic scoping review and evidence map.xlsx Zihang Zhao (20505904) Yousheng Zhang (1626661) Zihan Liu (5174729) Qianye Li (25087624) Teng Pan (6550055) Shuo Yang (209399) Xin Wang (91924) Lianxin Song (22850530) Zhuoyi Li (7348397) Ruipeng Zhang (4603846) Zhiyong Hou (456547) Cell Metabolism adipokines cardiometabolic disorders diabetes evidence map exercise exerkines extracellular vesicles myokines Background<p>Exercise-responsive endocrine-metabolic mediators may contribute to the systemic cardiometabolic adaptations induced by physical activity, but the literature spans diverse mediator classes, exercise paradigms, disease contexts, and experimental models. We conducted a systematic scoping review and evidence map to characterize the structure of this evidence and the biological relations examined across the field.</p>Methods<p>PubMed/MEDLINE, Web of Science Core Collection, and Scopus were searched from database inception through 7 August 2026. Titles and abstracts, followed by full texts, were independently assessed by two reviewers, with third-reviewer adjudication where required. Eligible primary reports underwent a separate round of independent full-text data charting using a relational framework linking reports, exercise contrasts, and mediator evidence. Cardiometabolic contexts and outcome domains were coded using multi-label rules, synonymous mediator terminology was harmonized, and companion publications were linked before study-level synthesis. Six potentially co-occurring evidence relations were mapped: exercise responsiveness, cardiometabolic association, source/secretion evidence, receptor/pathway evidence, functional perturbation, and formal mediation.</p>Results<p>The searches yielded 3,388 records, of which 1,535 unique records underwent title/abstract screening and 397 reports underwent full-text assessment. The final primary evidence map comprised 365 reports representing 363 underlying studies, 413 exercise contrasts, 776 mediator-evidence observations, and 103 harmonized named mediators. Obesity/overweight was represented in 78.0% of studies. Among the 308 studies contributing named mediators, adipokines were represented in 58.4%, cytokines/chemokines in 32.1%, and myokines in 25.6%. Adiponectin, leptin, IL-6, and irisin were the most frequently represented named mediators. Exercise-responsive evidence and cardiometabolic associations were identified in 90.9% and 87.0% of contributing studies, respectively, whereas source/secretion evidence (18.5%), receptor/pathway evidence (9.7%), functional perturbation (11.4%), and formal mediation (0.3%) were less frequently represented. Chronic training accounted for 81.6% of exercise contrasts and aerobic/endurance exercise for 63.4%.</p>Conclusions<p>Exercise-responsive mediator research in cardiometabolic disease comprises a concentrated group of recurrent adipokines, cytokines, and myokines alongside a broad, sparsely studied mediator landscape. Exercise-responsive evidence and cardiometabolic associations were frequently represented, whereas direct investigation of tissue source, downstream pathways, functional perturbation, and formal mediation was less common. Studies integrating well-characterized exercise exposures with serial mediator assessment, source validation, and mechanistic testing may help define how exercise-responsive signaling contributes to cardiometabolic adaptation.</p> 2026-09-22T05:30:12Z Dataset Dataset 10.3389/fendo.2026.1892959.s001 https://figshare.com/articles/dataset/Supplementary_file_2_Exercise-responsive_endocrine-metabolic_mediators_in_diabetes_and_cardiometabolic_disorders_a_systematic_scoping_review_and_evidence_map_xlsx/33961912 CC BY 4.0