2026-10-11T13:36:53Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33961812 2026-09-22T05:05:03Z category_1 category_4 category_146 category_915 category_7 category_12 category_14 category_21 category_39 category_61 category_133 portal_63 item_type_2 month_year_09_2026

Nanoparticle-Mediated Synthesis of Single-Crystal Covalent Organic Frameworks of Uniform Size and Shape Ji Ao (19188332) Xinyu Zhang (14029) Zeqi Li (6371579) Barry Chi Hong Lai (25087461) Wendi Duan (11719898) Zhisheng Wang (804429) Seungkyu Lee (1314678) Yoonseob Kim (1454815) Yijiang Mu (11719895) Yufeng Wang (274657) Biophysics Biochemistry Space Science Physical Sciences not elsewhere classified Medicine Cell Biology Molecular Biology Biotechnology Ecology Developmental Biology Plant Biology promote burst nucleation nonclassical crystallization pathways method also extends based crystalline materials tune cof morphologies prevent crystal aggregation g ., cof shape remain elusive crystal surface crystal microparticles based cofs work paves superstructures reflecting shape uniformity molecule modulation mediated strategy common small anisotropic shape The synthesis of highly crystalline covalent organic frameworks (COFs) has recently been achieved, but strategies to obtain monodispersed single crystals of uniform size and shape remain elusive. Here, we show that simply adding silica nanoparticles (SiNPs) to a conventional solvothermal synthesis directs imine-based COFs (e.g., COF-300) to grow into monodispersed, polyhedral single-crystal microparticles. Our experiments suggest dual functions of these nanoparticles. They promote burst nucleation of COFs via monomer adsorption and, then, by adhering to the crystal surface, prevent crystal aggregation and nonclassical crystallization pathways. This nanoparticle-mediated strategy is compatible with common small-molecule modulation to tune COF morphologies and shapes while maintaining low size dispersity. The method also extends to other three-dimensional (3D) imine COFs, such as LZU-111 and LZU-79. Notably, the obtained microcrystals show excellent colloidal stability and can assemble into superstructures reflecting their anisotropic shape. This work paves the way for COF-based crystalline materials and applications where size and shape uniformity are essential. 2026-09-22T00:00:00Z Dataset Media 10.1021/jacs.6c13136.s004 https://figshare.com/articles/media/Nanoparticle-Mediated_Synthesis_of_Single-Crystal_Covalent_Organic_Frameworks_of_Uniform_Size_and_Shape/33961812 CC BY-NC 4.0