2026-10-13T10:42:38Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33961396 2026-09-22T04:18:11Z category_15 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Association between atherogenic dyslipidemia and DBS-derived p-tau217 in older adults: evidence from SHARE DBS data.pdf Zunwei Wang (23099728) Yanyan Liu (171941) Xiaofei Sun (196958) Yitong Ling (16752435) Neuroscience Alzheimer’s disease atherogenic index of plasma dried blood spot dyslipidemia phosphorylated tau 217 SHARE Background<p>Atherogenic dyslipidemia has been associated with adverse cognitive and dementia-related outcomes, but its relationship with Alzheimer’s disease-related blood biomarkers remains unclear.</p>Objective<p>To examine whether the atherogenic index of plasma (AIP) is associated with dried blood spot (DBS)-derived phosphorylated tau 217 (p-tau217) in older adults from Germany, Sweden, and Denmark.</p>Materials and methods<p>This cross-sectional analysis included adults aged ≥50 years from Germany, Sweden, and Denmark in the Survey of Health, Ageing and Retirement in Europe DBS biomarker substudy. AIP was calculated as log10(triglycerides/high-density lipoprotein cholesterol). Multivariable linear regression with robust standard errors evaluated standardized natural log-transformed p-tau217, with additional dose–response analyses, comparisons across neurological biomarkers, and sensitivity analyses.</p>Results<p>Among 2,676 participants, a 1-SD higher AIP was associated with a 0.074-SD higher ln(p-tau217) (95% CI, 0.034–0.115; p < 0.001), corresponding after back-transformation to a 5.2% higher adjusted geometric mean DBS-derived p-tau217 concentration (95% CI, 2.3–8.1%). The highest versus lowest AIP quartile was associated with higher p-tau217 (β, 0.162; 95% CI, 0.052–0.272; p = 0.004), although estimates across quartiles were not strictly monotonic. Associations were statistically supported for p-tau217 and total tau, but not for GFAP or NfL after FDR correction. Results were robust in sensitivity analyses.</p>Conclusion<p>In this cross-sectional analysis, higher AIP, reflecting atherogenic dyslipidemia, was associated with a modestly higher DBS-derived p-tau217 concentration in older adults. The biological and clinical significance of this association remains to be established in longitudinal and multimodal studies.</p> 2026-09-22T04:18:11Z Dataset Dataset 10.3389/fnagi.2026.1948518.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Association_between_atherogenic_dyslipidemia_and_DBS-derived_p-tau217_in_older_adults_evidence_from_SHARE_DBS_data_pdf/33961396 CC BY 4.0