2026-10-14T07:45:28Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33959751 2026-09-21T19:15:30Z category_7 category_14 category_16 category_19 category_46 category_734 category_106 category_128 category_132 portal_87 item_type_3 month_year_09_2026

The role of the atherogenic index of plasma in response to once-daily tadalafil in men with erectile dysfunction Cem Tuğrul Gezmiş (25085346) Nusret Can Çilesiz (25085349) Mehmet Uzut (22769978) Mustafa Satılmışoğlu (25085352) Ali Eroğlu (25085355) Buğra Çetin (25085358) Mahmut Selman Mert (25085361) Mustafa Bahadır Can Balcı (22769987) Medicine Molecular Biology Physiology Pharmacology Immunology Biological Sciences not elsewhere classified Science Policy Hematology Infectious Diseases Erectile dysfunction tadalafil atherogenic index of plasma treatment outcome phosphodiesterase 5 inhibitors <p>Erectile dysfunction (ED) significantly affects quality of life, and phosphodiesterase type 5 inhibitors, including tadalafil, are main treatment options. Treatment response varies, and vasculometabolic disturbances may reduce responsiveness.</p> <p>In this prospective single-centre cohort study, men aged ≥40 years with ED initiating tadalafil 5 mg once daily were followed for 12 weeks. AIP was calculated as log₁₀(triglycerides/HDL-C) after conversion to mmol/L. The primary outcome was a ≥4-point increase in IIEF-EF. Firth penalised logistic regression and ROC analyses were performed.</p> <p>Among 134 men, the response rate was 73.1%. Nonresponders had higher baseline AIP (0.196 ± 0.271 vs 0.070 ± 0.224, <i>p </i>= 0.008), higher BMI (28.8 ± 4.19 vs 27.4 ± 3.28 kg/m², <i>p </i>= 0.042), and higher prevalence of DM (30.6% vs 12.2%, <i>p </i>= 0.013). Each 0.1-unit AIP increase was independently associated with nonresponse (adjusted OR 1.20, 95% CI 1.01–1.44, <i>p </i>= 0.036), as was DM (adjusted OR 3.39, 95% CI 1.15–10.45, <i>p </i>= 0.027). ROC analysis yielded an AUC of 0.650 (95% CI 0.540–0.760, <i>p </i>= 0.008), with an optimal cutoff of 0.130.</p> <p>Higher baseline AIP was independently associated with nonresponse to once-daily tadalafil in men with ED, suggesting AIP may offer additional prognostic information, though further validation is needed.</p> <p></p><p>The atherogenic index of plasma (AIP), derived from routine lipid measurements, may provide simple pretreatment information in men with erectile dysfunction initiating once-daily tadalafil.</p><p>Higher baseline AIP levels were associated with a lower likelihood of clinically meaningful response to tadalafil in this cohort.</p><p>Diabetes mellitus was also independently associated with nonresponse, supporting the importance of broader metabolic assessment in erectile dysfunction management.</p><p>Given its modest discriminatory ability, AIP should be considered a potential adjunctive marker rather than a stand-alone clinical decision tool.</p><p></p> <p>The atherogenic index of plasma (AIP), derived from routine lipid measurements, may provide simple pretreatment information in men with erectile dysfunction initiating once-daily tadalafil.</p> <p>Higher baseline AIP levels were associated with a lower likelihood of clinically meaningful response to tadalafil in this cohort.</p> <p>Diabetes mellitus was also independently associated with nonresponse, supporting the importance of broader metabolic assessment in erectile dysfunction management.</p> <p>Given its modest discriminatory ability, AIP should be considered a potential adjunctive marker rather than a stand-alone clinical decision tool.</p> 2026-09-21T19:15:30Z Dataset Dataset 10.6084/m9.figshare.33959751.v1 https://figshare.com/articles/dataset/The_role_of_the_atherogenic_index_of_plasma_in_response_to_once-daily_tadalafil_in_men_with_erectile_dysfunction/33959751 CC BY 4.0