2026-10-14T00:27:03Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33955488 2026-09-21T17:17:17Z category_7 category_15 category_21 category_46 category_734 category_106 category_122 portal_87 item_type_3 month_year_09_2026

Psychiatric comorbidities in people with and without post-traumatic epilepsy: a systematic review and meta-analysis Ali Rafati (17585268) Aditya Mittal (248200) Churl-Su Kwon (6340136) Medicine Neuroscience Biotechnology Immunology Biological Sciences not elsewhere classified Science Policy Mental Health Post-traumatic epilepsy traumatic brain injury comorbidity psychiatric mental health <p>While both traumatic brain injury (TBI) and epilepsy are independently associated with psychiatric comorbidities, population-based evidence on the association between post-traumatic epilepsy (PTE) and psychiatric comorbidities is limited. We systematically reviewed psychiatric comorbidities in people with vs. without PTE.</p> <p>We followed PRISMA reporting standards. Records were searched until August 2026 from MEDLINE, Embase, and PsycINFO, and were included if reported psychiatric comorbidities among people with PTE compared to control groups of i) epilepsy, ii) TBI-no-epilepsy, and/or iii) no-TBI-no-epilepsy.</p> <p>Of 1275 records identified, 6 were included. Sufficient data for meta-analysis was available only for depression. A pooled analysis of 2 studies on 81 people with PTE and 515 people with TBI-no-epilepsy showed no significantly different incidence proportion of depression between PTE and TBI-no-epilepsy (24/81[29.6%] vs. 121/515[23.4%]; RR:1.20 95%CI:0.83–1.74).</p> <p>Previous evidence is sparse. We observed no significant difference in depression incidence in PTE vs. TBI-no-epilepsy. Future research should explore psychiatric comorbidities in PTE vs. TBI-no-epilepsy, epilepsy-only, and healthy controls.</p> <p></p><p>1. Only 8 studies met the inclusion criteria, showing a major evidence gap in comparative data on psychiatric comorbidities in PTE versus TBI-only, epilepsy-only, or no TBI/no epilepsy controls.</p><p>2. Depression incidence showed no significant difference between PTE and TBI without epilepsy in the available 1-year follow-up data, underscoring the need for standardized, severity-stratified studies across more ILAE regions.</p><p></p> <p>1. Only 8 studies met the inclusion criteria, showing a major evidence gap in comparative data on psychiatric comorbidities in PTE versus TBI-only, epilepsy-only, or no TBI/no epilepsy controls.</p> <p>2. Depression incidence showed no significant difference between PTE and TBI without epilepsy in the available 1-year follow-up data, underscoring the need for standardized, severity-stratified studies across more ILAE regions.</p> 2026-09-21T17:17:17Z Dataset Dataset 10.6084/m9.figshare.33955488.v1 https://figshare.com/articles/dataset/Psychiatric_comorbidities_in_people_with_and_without_post-traumatic_epilepsy_a_systematic_review_and_meta-analysis/33955488 CC BY 4.0