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oai:figshare.com:article/33953140 2026-09-21T12:51:07Z category_325 category_362 category_139 category_15 category_367 category_662 category_153 category_410 category_319 portal_316 item_type_3 month_year_09_2026

Table_1_Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES database.docx Rulin Geng (14234099) Yu Zhang (12946) Miao Liu (148274) Shengfeng Deng (14234102) Jingwen Ding (3992732) Hongfei Zhong (14234105) Qiuyun Tu (4762518) Clinical Sciences not elsewhere classified Central Nervous System Pathology Neuroscience Aged Care Nursing Protein Trafficking Health Care Aged Health Care Psychiatry (incl. Psychotherapy) cognitive function dementia Alzheimer’s disease serum uric acid NHANES Background<p>The many studies revealing a connection between serum uric acid (SUA) and dementia have reported conflicting results. This study sought to investigate the relations between SUA and cognitive function in older adults.</p>Materials and methods<p>The sample was 2,767 American adults aged ≥60 years from the National Health and Nutrition Examination Survey 2011–2014. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer’s Disease test, animal fluency test, digit symbol substitution test, and composite z-score. Multivariate linear regression analyses were conducted to estimate the association between SUA and cognitive function.</p>Results<p>SUA level and cognitive function were significantly, positively correlated. Age significantly correlated with the association between SUA and cognitive function.</p>Conclusion<p>These findings support a connection between SUA and cognition, showing a positive link between SUA and cognitive scores among older American adults. We contend that a slight rise in uric acid within the normal range is advantageous for enhanced cognition. To confirm the precise dose-time-response relation, more tests will be needed.</p> 2026-09-21T12:51:07Z Dataset Dataset 10.3389/fnagi.2022.1024415.s001 https://figshare.com/articles/dataset/Table_1_Elevated_serum_uric_acid_is_associated_with_cognitive_improvement_in_older_American_adults_A_large_population-based-analysis_of_the_NHANES_database_docx/33953140 CC BY 4.0