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oai:figshare.com:article/33952454 2026-09-21T12:18:23Z category_1 category_4 category_146 category_8 category_19 category_21 category_272 category_873 category_64 category_132 portal_63 item_type_2 month_year_09_2026

Macrophage-Inspired Fe₃O₄ Nanozymes with a Hydrophobic Spiky Topography for Treating Drug-Resistant Bacteria Jia-Cheng Lv (10826746) Shi-Peng Chen (12244648) Yu-Qing Wei (25083443) Ming Yan (284631) Zhi-Guo Wang (397212) Su-Jiao Cao (25083446) Jia-Zhuang Xu (1283538) Li Qiu (242627) Zhong-Ming Li (1283526) Biophysics Biochemistry Space Science Microbiology Pharmacology Biotechnology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Cancer Infectious Diseases ros generation sites microenvironment engineering strategy insect wing micro hydrophobic spiky topography hydrophobic nanoneedle surface hydrophobic carbon shell densely aligned nanoneedles band centers toward enhanced bacterial adhesion fold higher pod like bacterial capture resistant bacteria fe first reported nanozyme 4 </ sub 3 </ sub 2 </ sub yielding 2 bacterial membranes nanozyme achieved like activity fold lower first fda work offers treating drug pristine fe nanoparticles encapsulated hydrogen bonding holds promise fermi level engineered fe designed fe based nanomaterial architecture shifted approved transition antibacterial therapy advance fe Fe₃O₄, the first reported nanozyme and the first FDA-approved transition-metal-based nanomaterial, holds promise for antibacterial therapy but is limited by poor ROS catalytic activity and utilization. Inspired by macrophage-like bacterial capture and insect wing micro/nanostructures, we designed Fe₃O₄ nanoparticles encapsulated in a conductive, hydrophobic carbon shell with densely aligned nanoneedles. This architecture shifted the Fe/O d/p-band centers toward the Fermi level, promoted H₂O₂ adsorption and activation, and strengthened H₂O₂ homolysis through H₂O₂–O hydrogen bonding, yielding 2.67-fold higher POD-like activity than that of pristine Fe₃O₄. The hydrophobic nanoneedle surface further inhibited continuous liquid film formation, enhanced bacterial adhesion, and shortened the distance between ROS generation sites and bacterial membranes, thereby improving ROS utilization. Consequently, the engineered Fe₃O₄ nanozyme achieved an MRSA inhibitory concentration nearly 15-fold lower than pristine Fe₃O₄. This work offers a microenvironment engineering strategy to advance Fe₃O₄-based antibacterial nanozymes toward clinical translation. 2026-09-21T00:00:00Z Dataset Media 10.1021/acs.nanolett.6c02274.s001 https://figshare.com/articles/media/Macrophage-Inspired_Fe_sub_3_sub_O_sub_4_sub_Nanozymes_with_a_Hydrophobic_Spiky_Topography_for_Treating_Drug-Resistant_Bacteria/33952454 CC BY-NC 4.0