2026-10-07T06:13:38Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33951250 2026-09-21T10:26:59Z category_24199 category_24187 category_24310 category_24700 category_24508 item_type_3 month_year_09_2026

Thesis: Supplementary Datasets and Resources Evans A. Adu (7524140) Sequence analysis Biological network analysis Genomics Medical parasitology Infectious diseases Comparative Genomics Functional Genomics Systems Biology Computational Biology Protein Structure and Function Network Biology Drug Target Discovery <p dir="ltr">This repository contains the supplementary datasets generated during a doctoral research project investigating schistosome adhesion and lipid acquisition networks through comparative genomics, orthology analysis, domain architecture profiling, phylogenetics, and network-based target prioritisation. The collection includes curated protein catalogues, orthogroup assignments, phylogenetic classifications, conserved motif annotations, membrane topology predictions, functional module classifications, evidence-based confidence assessments, and prioritisation outputs for candidate proteins across <i>Schistosoma mansoni</i>, <i>S. haematobium</i>, and <i>S. japonicum</i>.</p><p dir="ltr">The final adhesome dataset has been integrated into an interactive <a href="https://thesis-h5trcx3waczuh7mvz5l7af.streamlit.app/" target="_blank" rel="noreferrer">Streamlit-based atlas</a> that provides standardised protein identifiers, species distributions, predicted orthology relationships, domain architectures, conserved motifs, membrane topology, functional modules, phylogenetic classifications, network positions, evidence levels, and prioritisation scores.</p><p dir="ltr">All custom scripts used for data retrieval, processing, annotation, orthology inference, phylogenetic reconstruction, network analysis, prioritisation, and atlas generation are maintained under version control and are publicly available at <a href="https://github.com/EvansKCCR/Thesis" target="_blank" rel="noopener noreferrer">GitHub Repository</a>.</p><p dir="ltr">Primary input datasets were obtained from <a href="https://parasite.wormbase.org/" target="_blank" rel="noopener noreferrer">WormBase ParaSite</a> and <a href="https://www.ncbi.nlm.nih.gov/datasets/taxonomy/9606/" target="_blank" rel="noreferrer">NCBI-NLM-NIH</a>. These resources provided the reference proteomes and genomic annotations used throughout the study.</p><p dir="ltr">The datasets are provided to support transparency, reproducibility, and reuse of the computational workflows and research outputs described in the associated thesis.</p> 2026-09-21T10:26:59Z Dataset Dataset 10.6084/m9.figshare.33951250.v1 https://figshare.com/articles/dataset/Thesis_Supplementary_Datasets_and_Resources/33951250 CC BY 4.0