2026-10-14T15:42:28Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33951166 2026-09-21T11:14:29Z category_24184 item_type_3 month_year_09_2026

Weak, context-dependent conservation of RNA–protein dispersion between human and Arabidopsis Yanying An (25078033) Ran Wanf (25083128) Bioinformatic methods development bioinformatics algorithms course Background. RNA and protein abundance are imperfectly coupled across biological tissues, yet it remains unclear whether gene-specific RNA–protein phenotypes are conserved across deeply diverged multicellular kingdoms.Methods. We integrated tissue-resolved transcriptomic and proteomic atlases from human and Arabidopsis thaliana to test whether relative RNA-versus-protein dispersion is conserved among ancient one-to-one orthologs. For each gene, we defined Bdisp as the difference between the quartile coefficient of dispersion of RNA and protein abundance across within-species tissues or conditions, quantifying the relative extent of tissue-level RNA and protein variation without requiring cross-kingdom tissue equivalence. Generalizability was evaluated in an independent mouse aging atlas (seven tissues, four ages) and a Brassica rapa heat-stress RNA–protein dataset. 2026-09-21T11:14:29Z Dataset Dataset 10.6084/m9.figshare.33951166.v2 https://figshare.com/articles/dataset/Weak_context-dependent_conservation_of_RNA_protein_dis-persion_between_human_and_Arabidopsis/33951166 CC BY 4.0