2026-10-12T08:53:44Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33949207 2026-09-21T04:31:48Z category_303 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Hidden burden of pneumococcal colonization in adults with viral respiratory infections: the role of influenza and RSV.pdf Rocío España-Bonilla (21739097) Sara Calvo-Silveria (21739091) Aida González-Díaz (7400762) Júlia Guevara-Figueras (24756106) Lucía Fernández-Delgado (21739094) Catalina Medina-Gómez (25079980) Laura Calatayud (217408) Jordi Niubó (6997034) Mercè Gasa (25079983) Gabriela Abelenda-Alonso (14098180) M. Ángeles Domínguez (5656297) Judith Peñafiel (509506) Carmen Ardanuy (310594) Jordi Càmara (3910963) Clinical Microbiology colonization IAV infection pneumococcal vaccines Streptococcus pneumoniae viral infection Introduction<p>Although pneumococcal colonization is uncommon in adults, it may increase during respiratory viral infections. We investigated the frequency of pneumococcal colonization, associated factors, and serotype distribution in adults with confirmed respiratory viral infection.</p>Methods<p>We prospectively included adults presenting to the Emergency Department of Bellvitge University Hospital with influenza A virus (IAV), SARS-CoV-2, or respiratory syncytial virus (RSV) infection, as well as 33 virus-negative controls (December 2023–January 2024). Nasopharyngeal swabs were tested for Streptococcus pneumoniae using a RT-PCR assay (lytA and piaB genes). Clinical data were analysed using Cox proportional hazards regression models.</p>Results<p>A total of 616 episodes were studied (IAV, n=391; SARS-CoV-2, n=162; RSV, n=28; >1 virus, n=35). Pneumococcal colonization was detected in 85 individuals, with the highest prevalence among IAV-infected patients (14.8%), followed by RSV (10.7%) and SARS-CoV-2 (9.3%). Individuals with viral infection showed higher pneumococcal loads (median lytA C_T 23.1 [18.7–27.4]) compared to those without infection (C_T 31.8 [31.5–33.3]). IAV (OR 3.52; 95%CI 1.30–9.17) and RSV (OR 4.04; 95%CI 1.11–13.50) were independently associated with pneumococcal colonization. Among adults <65 years, female sex (OR for male sex 0.43; 95% CI 0.19–0.90) was associated with colonization, whereas in those ≥65 years, RSV infection (OR 5.56; 95% CI 1.03–27.31) was the main association. Detected serotypes were diverse, predominantly non-PCV serotypes.</p>Conclusions<p>Pneumococcal colonization was more frequent during IAV or RSV than SARS-CoV-2 infection. In older adults, RSV infection showed a particularly strong association, highlighting potential implications for pneumococcal and RSV vaccination strategies.</p> 2026-09-21T04:31:48Z Dataset Dataset 10.3389/fcimb.2026.1929747.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Hidden_burden_of_pneumococcal_colonization_in_adults_with_viral_respiratory_infections_the_role_of_influenza_and_RSV_pdf/33949207 CC BY 4.0