2026-10-13T13:11:51Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33948625 2026-09-21T04:22:49Z category_363 portal_316 item_type_3 month_year_09_2026

Supplementary file 1_Hypothalamic subregional volume in relation to VSS-C total symptom burden in women with migraine: an exploratory cross-sectional MRI study.docx Linyi Che (25079653) Wanqun Hu (25079656) Xiaoping Fan (699924) Qinlian Huang (25079659) Ruonan Zhang (358761) Yuhui Xu (525146) Liang Dong (381161) Li Jiang (120930) Jiying Zhou (2361544) Neurology and Neuromuscular Diseases dizziness hypothalamus migraine structural MRI Vertigo Symptom Scale vestibular symptoms Background<p>Dizziness, vertigo, and related autonomic symptoms are common in migraine, but whether their combined symptom-frequency burden is associated with hypothalamic subregional structure remains unclear.</p>Methods<p>This exploratory cross-sectional secondary analysis included 39 women with ICHD-3-defined migraine. All source T1-weighted images were processed uniformly with FreeSurfer 7.4.1 and automated hypothalamic subunit segmentation. Blinded quality control was performed without clinical data and independently confirmed by a neuroradiologist. The exposure was VSS-C total score, a composite of vertigo-balance and autonomic-anxiety symptom frequency. Models for five bilateral subunits and whole-hypothalamus volume adjusted for age, estimated total intracranial volume, and baseline monthly migraine days; Benjamini-Hochberg false-discovery-rate correction was applied across the six outcomes. Outcome-specific quality-control denominators were 37 or 39.</p>Results<p>Anterior-superior hypothalamic volume was associated with VSS-C total score (n = 39; β = 0.165 mm³ per point, 95% confidence interval 0.064 to 0.266, p = 0.0021; BH-FDR-adjusted p = 0.0127). The association remained after restricting all six outcomes to the same 37 participants (BH-FDR-adjusted p = 0.0334). Across the observed 20-point VSS-C interquartile range, the coefficient corresponded to 3.31 mm³, or 8.54% of mean anterior-superior volume. DHI identified the same subregion in a separately corrected supporting analysis, but mutual adjustment attenuated both coefficients.</p>Conclusion<p>Higher VSS-C total symptom burden was associated with larger anterior-superior hypothalamic volume in women with migraine. This result identifies a subregional target for prospective replication with component-level symptom assessment and formal vestibular phenotyping.</p> 2026-09-21T04:22:49Z Dataset Dataset 10.3389/fneur.2026.1931533.s001 https://figshare.com/articles/dataset/Supplementary_file_1_Hypothalamic_subregional_volume_in_relation_to_VSS-C_total_symptom_burden_in_women_with_migraine_an_exploratory_cross-sectional_MRI_study_docx/33948625 CC BY 4.0