2026-10-09T09:14:12Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33946465 2026-09-21T02:08:54Z category_24178 category_24145 item_type_3 month_year_09_2026

Neuronal LAMTOR1 Upregulation Impairs the Autophagy-Lysosomal System in Alzheimer's Disease Brains shengzhou Wu (22341388) Biochemistry and cell biology not elsewhere classified Cell neurochemistry H+-ATPase autophagy arrest mtorc1-dependent TFEB-dependent <p dir="ltr">​Dysfunction of the autophagy-lysosomal system is critically involved in the pathogenesis of Alzheimer's diseases (AD). LAMTOR1 is an adaptor protein that resides on late endosomes and lysosomes and participates in the regulation of cellular metabolism and stress responses. This study explore the expression pattern of LAMTOR1 in the AD-affected brains and its roles in AD.</p> 2026-09-21T02:08:54Z Dataset Dataset 10.6084/m9.figshare.33946465.v1 https://figshare.com/articles/dataset/Neuronal_LAMTOR1_Upregulation_Impairs_the_Autophagy-Lysosomal_System_in_Alzheimer_s_Disease_Brains/33946465 CC BY 4.0