2026-10-12T22:13:00Z
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2026-09-20T18:29:11Z
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Phomporone A, a new cytosporone derivative from mangrove-derived fungus <i>Phomopsis asparagi</i> ZMU-35-1
Chu-Ling Wu (25078172)
Zu-Yan Zhong (25078175)
Wei-Zhen Long (25078178)
Min Wang (21070)
Si-Wen Yuan (5370587)
Biochemistry
Microbiology
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Ecology
Biological Sciences not elsewhere classified
Hematology
Infectious Diseases
Plant Biology
Phomporone A
phomopsis asparagi
mangrove-derived fungus
antifungal activity
<p>A new polyketide, phomporone A (<b>1</b>), along with three related analogues, cytosporone P (<b>2</b>), cytosporone Q (<b>3</b>), and cytosporone E (<b>4</b>) were isolated from the mangrove-derived fungus <i>Phomopsis asparagi</i> ZMU-35-1. The chemical structures of these compounds were elucidated through comprehensive spectroscopic analysis, including 1D and 2D NMR and high-resolution electrospray ionisation mass spectrometry (HR-ESIMS), and by comparison with previously reported spectral data. The antifungal activities of compounds <b>1</b>–<b>4</b> were evaluated against a panel of phytopathogenic fungi. Compound <b>1</b> exhibited inhibitory activity against <i>Botryosphaeria dothidea</i> and <i>Fusarium graminearum</i>, with minimum inhibitory concentration (MIC) values of 50 and 100 μg/mL, respectively. Compound <b>2</b> showed moderate activity against <i>Alternaria alternata</i> with an MIC value of 100 μg/mL. Notably, compound <b>4</b> displayed the most potent and broad-spectrum antifungal profile, inhibiting <i>B. dothidea</i>, <i>Valsa mali</i> Miyabe & G. Yamada and <i>A. alternata</i>, and with MIC values of 6.25, 50, and 100 μg/mL, respectively.</p>
2026-09-20T18:29:11Z
Dataset
Dataset
10.6084/m9.figshare.33945842.v1
https://figshare.com/articles/dataset/Phomporone_A_a_new_cytosporone_derivative_from_mangrove-derived_fungus_i_Phomopsis_asparagi_i_ZMU-35-1/33945842
CC BY 4.0