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oai:figshare.com:article/33939795 2026-09-18T17:53:26Z category_1 category_915 category_12 category_16 category_24 category_122 portal_5 item_type_2 month_year_09_2026

<p>Trajectory comparison with and without directional cue for migrating systems.</p> Zeno Messi (25073571) Franck Raynaud (5745788) Nathan W. Goehring (20404690) Alexander B. Verkhovsky (25073574) Biophysics Physical Sciences not elsewhere classified Cell Biology Physiology Evolutionary Biology Mental Health sufficiently high levels recent experimental findings initially distributed uniformly adhesion dynamics could simple turnover rules several turnover cycles low turnover rates intermediate turnover rates high turnover rates fundamental emergent behavior xlink "> polarization adhesion drive polarization drive symmetry breaking breaking symmetry solely directional motion emerged anchors hindered motion threshold force required attractive force dipoles minimal model consists elastic cytoskeletal network complex signaling networks simple mechanical network sensitive anchor points symmetry breaking signaling networks network behavior turnover rate anchor points network accumulated elastic bonds mechanical interactions anchor removal traction force dipole force substrate adhesions retraction transitions results demonstrate primarily determined plasma membrane intrinsic property fully understood external cues eventually exceeding balanced contractility <p>Comparison of trajectories of systems with different level of external cue. (Top) no cue, (middle) gradient 2, (bottom) gradient 4. Outline and trajectory of each system is shown in black and red respectively. All simulations were generated from the same set of parameters that corresponds to the migrating phenotype. The parameters for the simulation are: anchor density , dimensionless dipole force magnitude <i>M</i> = 4, anchor removal threshold .</p> <p>(AVI)</p> 2026-09-18T18:02:25Z Dataset Media 10.1371/journal.pcbi.1014750.s010 https://figshare.com/articles/media/_p_Trajectory_comparison_with_and_without_directional_cue_for_migrating_systems_p_/33939795 CC BY 4.0