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oai:figshare.com:article/33939789 2026-09-18T17:53:24Z category_1 category_915 category_12 category_16 category_24 category_122 portal_5 item_type_2 month_year_09_2026

<p>Force map timelapse of migrating system.</p> Zeno Messi (25073571) Franck Raynaud (5745788) Nathan W. Goehring (20404690) Alexander B. Verkhovsky (25073574) Biophysics Physical Sciences not elsewhere classified Cell Biology Physiology Evolutionary Biology Mental Health sufficiently high levels recent experimental findings initially distributed uniformly adhesion dynamics could simple turnover rules several turnover cycles low turnover rates intermediate turnover rates high turnover rates fundamental emergent behavior xlink "> polarization adhesion drive polarization drive symmetry breaking breaking symmetry solely directional motion emerged anchors hindered motion threshold force required attractive force dipoles minimal model consists elastic cytoskeletal network complex signaling networks simple mechanical network sensitive anchor points symmetry breaking signaling networks network behavior turnover rate anchor points network accumulated elastic bonds mechanical interactions anchor removal traction force dipole force substrate adhesions retraction transitions results demonstrate primarily determined plasma membrane intrinsic property fully understood external cues eventually exceeding balanced contractility <p>Timelapse of force maps generated by a typical simulation of the migrating phenotype. System outline is shown in yellow. Trajectory of the system centroid from the start of the simulation to the current position is shown in red. Magnitude of the force on nearby anchors is shown color-coded. The force is normalized at each frame by the maximum force on an anchor in the frame. Frame number is shown in the left-top corner. Reference for the simulation 1723538402 (same as <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014750#pcbi.1014750.g006" target="_blank">Fig 6C</a> (migrating)). Length of the simulation: 400 steps. The parameters for the simulation are: anchor density , dimensionless dipole force magnitude <i>M</i> = 2, anchor removal threshold . See methods for a description of the generation of the force maps.</p> <p>(AVI)</p> 2026-09-18T18:02:25Z Dataset Media 10.1371/journal.pcbi.1014750.s008 https://figshare.com/articles/media/_p_Force_map_timelapse_of_migrating_system_p_/33939789 CC BY 4.0