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oai:figshare.com:article/33939780 2026-09-18T17:53:20Z category_1 category_915 category_12 category_16 category_24 category_122 portal_5 item_type_2 month_year_09_2026

<p>Anisotropic growing system timelapse.</p> Zeno Messi (25073571) Franck Raynaud (5745788) Nathan W. Goehring (20404690) Alexander B. Verkhovsky (25073574) Biophysics Physical Sciences not elsewhere classified Cell Biology Physiology Evolutionary Biology Mental Health sufficiently high levels recent experimental findings initially distributed uniformly adhesion dynamics could simple turnover rules several turnover cycles low turnover rates intermediate turnover rates high turnover rates fundamental emergent behavior xlink "> polarization adhesion drive polarization drive symmetry breaking breaking symmetry solely directional motion emerged anchors hindered motion threshold force required attractive force dipoles minimal model consists elastic cytoskeletal network complex signaling networks simple mechanical network sensitive anchor points symmetry breaking signaling networks network behavior turnover rate anchor points network accumulated elastic bonds mechanical interactions anchor removal traction force dipole force substrate adhesions retraction transitions results demonstrate primarily determined plasma membrane intrinsic property fully understood external cues eventually exceeding balanced contractility <p>Timelapse of a typical simulation of the anisotropic growing phenotype. Bonds are shown as black segments, dipoles as blue segments, and anchors as orange stars. Trajectory of the system centroid from the start of the simulation to the current position is shown in red. Grid size . Inset shows the outline of the system in black and the trace of the centroid in red. Reference for the simulation 1711535798 (same as <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014750#pcbi.1014750.g004" target="_blank">Fig 4G</a>-<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014750#pcbi.1014750.g004" target="_blank">4L</a>). Length of the simulation: 400 steps. The parameters for the simulation are: anchor density , dimensionless dipole force magnitude <i>M</i> = 4, anchor removal threshold .</p> <p>(AVI)</p> 2026-09-18T18:02:25Z Dataset Media 10.1371/journal.pcbi.1014750.s005 https://figshare.com/articles/media/_p_Anisotropic_growing_system_timelapse_p_/33939780 CC BY 4.0