2026-10-09T12:52:06Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33938889 2026-09-18T17:44:11Z category_7 category_16 category_21 category_45 category_64 category_106 category_132 category_135 portal_5 item_type_3 month_year_09_2026

<p>TPT surge data.</p> Phallon Blessing Mwaba (25073412) Innocent Mwaba (18158388) Minyoi Mubita Maimbolwa (18137037) Chitalu Chanda (21354901) Muhammad Mputu (24559881) Chola Lumbwe (25073415) Kevin Zimba (25073418) Nancy Kasese Chanda (25073421) Rhehab Chimzizi (41700) Angel Mubanga (19670074) Monde Muyoyeta (372849) Mary Kagujje (9362116) Medicine Physiology Biotechnology Sociology Cancer Science Policy Infectious Diseases Computational Biology tuberculosis preventive therapy thorough planning phase present programme data analyzed aggregate data 4226 ); one reduce tb incidence national tb programme th </ sup div >< p despite evidence showing based tpt initiation 89 high tb 5 %, n uptake among hiv negative tb contacts eligible household contacts tpt surge aimed zambia </ p 7 %, n 2 %, n tb contacts negative contacts negative individuals treatment due targeted implementation surge demonstrated stakeholder engagement programmatic rollout preferred regimen points increase months isoniazid month isoniazid january 2025 immediate 47 findings underscore facility registers driven approaches contact tracing 232 ). 001 ). &# 8211 <div><p>While tuberculosis preventive therapy (TPT) coverage among people living with HIV in Zambia has improved, uptake among HIV-negative contacts aged ≥5 years remains low. Despite evidence showing that TPT can reduce TB incidence by up to 60% in HIV-negative individuals, there is a paucity of evidence on programmatic rollout to this population in Zambia and the region. We present programme data from a TPT surge aimed at increasing uptake among ≥5 years old HIV-negative household TB contacts. The National TB Programme, with support from the TB Local Organizations Network, conducted a TPT surge in 89 high TB-burden facilities across eight project supported provinces in Zambia from October 2024–15^th January 2025. After a thorough planning phase, multidisciplinary teams conducted field visits for contact tracing and initiated TPT for eligible household contacts of bacteriologically confirmed TB.. Facility-based TPT initiation was provided for walk-in clients. We collected and analyzed aggregate data from facility registers. A total of 19,371 HIV-negative contacts aged ≥ 5 years were screened: 99.9% (n = 19,344) were eligible for and offered TPT. Of these, 72.4% (n = 14,000) were initiated on TPT, 2.0% (n = 385) refused and 26.2% (n = 4,959) were not initiated on treatment due to unavailability of their preferred regimen. The start of the surge was associated with an immediate 47.7% points increase in TPT coverage (p = 0.001). Overall, 63.7% (n = 8,917) were initiated on three-months Isoniazid+Rifapentine, followed by six-months Isoniazid (30.2%, n = 4226); one-month Isoniazid+Rifapentine (4.5%, n = 625) and on three-months Isoniazid+Rifampicin (1.7%, n = 232). The surge demonstrated that TPT can be rolled out to ≥5 years old HIV-negative TB contacts with high initiation rates achieved. This is achievable through targeted implementation, stakeholder engagement, and community-driven approaches. These findings underscore the feasibility of extending TPT to all TB contacts, regardless of HIV status or age, to accelerate TB prevention efforts in high-burden settings like Zambia.</p></div> 2026-09-18T17:44:08Z Dataset Dataset 10.1371/journal.pgph.0005628.s001 https://figshare.com/articles/dataset/_p_TPT_surge_data_p_/33938889 CC BY 4.0