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oai:figshare.com:article/33938163 2026-09-18T17:37:33Z category_13 category_21 category_46 category_734 category_61 category_64 category_106 portal_5 item_type_3 month_year_09_2026

<p>Categorisation of alpha-1 antitrypsin deficiency genotypes (SD = severe deficiency, NS = non-severe, N = normal).</p> Joshua De Soyza (24121959) Paul Ellis (6758159) Daniella Spittle (25073274) Anita Pye (17896389) Alice M. Turner (7950329) Genetics Biotechnology Immunology Biological Sciences not elsewhere classified Developmental Biology Cancer Science Policy minor adjustments reflecting mean age 54 larger multicentre datasets findings provide evidence 05 &# 8211 severe disease respectively severity score derived sectional data collection general bronchiectasis populations bronchiectasis severity index hazard ratio 1 1 antitrypsin deficiency lung function decline div >< p although prospective validation birmingham aatd registry cause bronchiectasis cohorts 1 %, 7 median bsi score 7 %, 23 severe aatd genotypes severe genotypes 7 %, cause bronchiectasis sgrq score clinical data 7 years confirmed bronchiectasis 4 %, ci 1 bsi score zz genotype study aimed specifically evaluated significant association sgrq ). related quality prognostic tool male ), increasingly recognised greater decline gas transfer alternative causes 8 %. 14 ). 002 ). 001 ), <p>Categorisation of alpha-1 antitrypsin deficiency genotypes (SD = severe deficiency, NS = non-severe, N = normal).</p> 2026-09-18T17:37:31Z Dataset Dataset 10.1371/journal.pone.0355956.s001 https://figshare.com/articles/dataset/_p_Categorisation_of_alpha-1_antitrypsin_deficiency_genotypes_SD_severe_deficiency_NS_non-severe_N_normal_p_/33938163 CC BY 4.0