2026-10-13T11:05:01Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33937943 2026-09-18T17:32:12Z category_7 category_15 category_16 category_21 category_873 category_122 portal_5 item_type_3 month_year_09_2026

<p>Overview of the flywheel training program for PD.</p> Juan Carlos Magaña (17442163) Silvia Enríquez-Calzada (25073228) Roger Prat (25073231) Cláudia M. Deus (12156084) Susana P. Pereira (20175557) Mercè Avellanet (13257759) Elvira Gea (25073234) Ariadna Laguna (9292013) Marta Martinez-Vicente (8489253) Ona Perez-Larumbe (25073237) Maria Giné-Garriga (424793) Jorge Hernández-Vara (11815482) Joel Montane (596156) Medicine Neuroscience Physiology Biotechnology Chemical Sciences not elsewhere classified Mental Health xlink "> exercise task training programs reach statistical significance randomized controlled trial analyzed using permutation parkinson &# 8217 tug times improved outcomes included quality current clinical trial task functional exercises intervention control group bdi ), lower basic physical training &# 8211 tug ). reported outcomes physical function pharmacological intervention evaluate clinical although bdi sts ), group differences functional mobility 524 ), week ). warrant confirmation three 60 sts gains stand test minute sit minute sessions mean difference limb strength group effects functional effects emotional well direct comparisons daily living bonferroni correction based anova 24 participants <div><p>Exercise is a promising non-pharmacological intervention for motor and non-motor symptoms in Parkinson’s disease (PD). However, direct comparisons between basic physical training (BPT) and dual-task training remain limited. The objective of the current clinical trial is to evaluate clinical and functional effects of BPT and a BPT combined with dual-task functional exercises (BPT + FE) in individuals with PD. In this randomized controlled trial, 24 participants with idiopathic PD were allocated to BPT, BPT + FE, or a no-intervention control group (Con). Interventions lasted 12 weeks (three 60-minute sessions/week). Outcomes included quality of life (PDQ-39), depressive symptoms (BDI), lower-limb strength (1-minute Sit-to-Stand Test, STS), and functional mobility (Timed Up and Go, TUG). Group effects were analyzed using permutation-based ANOVA with Bonferroni correction. Both interventions significantly improved physical performance vs. controls. STS gains were observed for BPT vs. Con (Mean Difference, MD = 31.00; p = .0026) and BPT + FE vs. Con (MD = 19.00; p = .0026). TUG times improved for BPT vs. Con (MD = –2.07s; p = .0039) and BPT + FE vs. Con (MD = –2.43s; p = .0028). Although BDI and PDQ-39 did not show statistically significant changes between group differences (r_rb = –0.429 and –0.339, respectively), several subscales demonstrated medium effect sizes suggesting potentially meaningful trends: emotional well-being (BPT: r_rb = –0.428; BPT + FE: r_rb = –0.446), bodily discomfort (BPT: r_rb = –0.524), and activities of daily living (BPT + FE: r_rb = –0.429). In conclusion, both programs improved physical performance in PD. Patient-reported outcomes did not reach statistical significance, but effect-size patterns suggest possible psychosocial benefits that warrant confirmation in larger trials.</p><p>Trial registration</p><p>ClinicalTrials.gov, <a href="https://clinicaltrials.gov/ct2/show/NCT05963425" target="_blank">NCT05963425</a>.</p></div> 2026-09-18T17:31:57Z Dataset Dataset 10.1371/journal.pone.0358534.t001 https://figshare.com/articles/dataset/_p_Overview_of_the_flywheel_training_program_for_PD_p_/33937943 CC BY 4.0