2026-10-12T01:00:51Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33934861 2026-09-29T11:13:03Z portal_1197 item_type_6 month_year_09_2026

The effect of benzocaine and ketoprofen gels on pain during fixed orthodontic appliance treatment : a randomised, double-blind, crossover trial Ladan Eslamian (8369754) Ali Borzabadi-Farahani (24729934) Hadi Gholami (1857994) Migrated from ePrints Aims: To compare the analgesic effect of topical benzocaine (5%) and ketoprofen (1.60 mg/ml) after 2 mm activation of 7 mm long delta loops used for maxillary en-masse orthodontic space closure. Subjects and methods: Twenty patients (seven males, 13 females, 15–25 years of age, mean age of 19.5 years) participated in a randomised crossover, double-blind trial. After appliance activation, participants were instructed to use analgesic gels and record pain perception at 2, 6, 24 hours and 2, 3 and 7 days (at 18.00 hrs), using a visual analogue scale ruler (VAS, 0–4). Each patient received all three gels (benzocaine, ketoprofen, and a control (placebo)) randomly, but at three different appliance activation visits following a wash-over gap of one month. After the first day, the patients were instructed to repeat gel application twice a day at 10:00 and 18:00 for three days. The recorded pain scores were subjected to non-parametric analysis. Results: The highest pain was recorded at 2 and 6 hours. Pain scores were significantly different between the three groups (Kruskal–Wallis test, p < 0.01). The overall mean pain rank levels and mean (SD) pain scores for the benzocaine 5%, ketoprofen, and control (placebo) groups were 182.19, 157.50, 201.8, and 0.89 (0.41), 0.68 (0.34), 1.15 (0.81), respectively. The pain scores were significantly different between the ketoprofen and control groups (mean difference = 0.47, p = 0.005). All groups demonstrated significant differences in pain scores at the six different time intervals (p < 0.05) and there was no gender difference (p > 0.05). Conclusion: A significant pain reduction was observed following the use of ketoprofen when tested against a control gel (placebo). The highest pain scores were experienced in patients administered the placebo and the lowest scores in patients who applied ketoprofen gel. Benzocaine had an effect mid-way between ketoprofen and the placebo. The highest pain scores were recorded 2 hours following force application, which decreased to the lowest scores at after 7 days. 2026-09-29T11:13:03Z Text Journal contribution 10.82444/warw.33934861 https://figshare.com/articles/journal_contribution/The_effect_of_benzocaine_and_ketoprofen_gels_on_pain_during_fixed_orthodontic_appliance_treatment_a_randomised_double-blind_crossover_trial/33934861 CC BY 4.0