2026-10-14T07:48:05Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33931315 2026-09-18T11:05:59Z category_1 category_4 category_146 category_7 category_13 category_21 category_873 category_39 category_132 portal_63 item_type_3 month_year_09_2026

A Convenient Conversion of Amides to Ketones Amy J. Su (25071730) Andrew W. Chen (18229738) Chunge Li (578430) Nick R. Wierich (25071733) Brenda Wu (25071736) Clare L. Phelps (25071739) Todd J. Martínez (1278021) Noah Z. Burns (1266771) Biophysics Biochemistry Space Science Medicine Genetics Biotechnology Chemical Sciences not elsewhere classified Ecology Infectious Diseases wet organic solvent protocol employs simple functional group transformations direct nitrogen deletion translates smoothly transformation proceeds structural scaffold rapid oxidation one pot n </ gram scale general route established syntheses convenient conversion commercial reagents classic motifs accessed via >- amination Amides are classic motifs for further functional group transformations because of their abundance and well-established syntheses. Herein we describe a general route to ketones from secondary amides through direct nitrogen deletion, preserving the remainder of the structural scaffold. The transformation proceeds through rapid oxidation of hydrazides, which are accessed via <i>N</i>-amination of the parent amides. Our protocol employs simple, commercial reagents in a wet organic solvent, open to air. This method can be performed in one pot and translates smoothly to gram scale, demonstrating a unique retrosynthetic logic toward ketone targets. 2026-09-18T00:00:00Z Dataset Dataset 10.1021/jacs.6c15781.s002 https://figshare.com/articles/dataset/A_Convenient_Conversion_of_Amides_to_Ketones/33931315 CC BY-NC 4.0