2026-10-12T10:43:14Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33922923 2026-09-18T07:30:36Z category_7 category_16 category_21 category_272 category_39 category_734 category_64 category_106 portal_87 item_type_3 month_year_09_2026

Epidemiology and treatment outcomes of bone and soft tissue sarcoma in pediatric and adolescent and young adult patients in Japan: data from population-based National Cancer Registry 2016–2019 Yu Toda (18389416) Koichi Ogura (5643719) Chigusa Morizane (13563541) Tomoyuki Satake (15166826) Shintaro Iwata (579054) Eisuke Kobayashi (3566198) Toshiyuki Takemori (7034015) Hiroya Kondo (2628967) Shudai Muramatsu (23328239) Takahiro Higashi (3436421) Akira Kawai (447839) Medicine Physiology Biotechnology Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified Cancer Science Policy Bone sarcoma Soft tissue sarcoma Pediatrics Adolescent and young adult (AYA) National cancer registry <p>This Japanese population-based retrospective study using National Cancer Registry data (2016–2019) revealed age-specific disparities in treatment and outcomes of bone and soft tissue sarcomas in patients under 40 years. A total of 1,209 bone sarcoma (BS) and 3,096 soft tissue sarcoma (STS) cases were analyzed for demographics, treatment modalities, survival rates, and prognostic factors. Osteosarcoma (53%) and Ewing sarcoma (15%) were the most common BS subtypes. Pediatric patients presented more frequently with metastases and received more chemotherapy, while surgery was performed in 80% of BS cases. For STS, fibrosarcoma (19%) and rhabdomyosarcoma (13%) predominated. AYA (adolescent and young adult) patients underwent more surgeries, whereas pediatric patients received more chemotherapy/radiotherapy. Three-year overall survival rates were 67% for BS and 79% for STS. Prognosis was significantly influenced by disease extent and surgical intervention. Age was an adverse prognostic factor for STS but not for BS. This first comprehensive Japanese population-based study demonstrates treatment disparities across age groups in sarcoma care. We revealed that pediatric and AYA sarcoma care in Japan shows clear age-related disparities.</p> 2026-09-18T07:30:36Z Dataset Dataset 10.6084/m9.figshare.33922923.v1 https://figshare.com/articles/dataset/Epidemiology_and_treatment_outcomes_of_bone_and_soft_tissue_sarcoma_in_pediatric_and_adolescent_and_young_adult_patients_in_Japan_data_from_population-based_National_Cancer_Registry_2016_2019/33922923 CC BY 4.0