2026-10-14T17:57:43Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33921656 2026-09-18T07:00:02Z category_7 category_15 category_16 category_45 category_46 category_122 portal_87 item_type_3 month_year_09_2026

Association of mRNA SARS-CoV-2 vaccination with fatigue and functional recovery in patients with post-acute sequelae of COVID-19 (PASC) Philipp Pries (25070711) Jan Fuge (532257) Michele Scharbau (25070714) Lennart Boblitz (25070717) Andrea Sauer (12539477) Nora Drick (8134809) Benjamin-Alexander Bollmann (25070720) Jannik Ruwisch (23077013) Marius M. Hoeper (9315867) Isabell Pink (9161943) Medicine Neuroscience Physiology Sociology Immunology Mental Health Exercise capacity fatigue PASC SARS-CoV-2 vaccination Patients with post-acute sequelae of SARS-CoV-2 (PASC) fear SARS-CoV-2 vaccine-linked symptom aggravation. Data on objective functional outcomes are limited. We performed a retrospective analysis of an observational cohort at a post-COVID outpatient clinic at Hannover Medical School with standardized assessments at baseline and follow-up visit (3–6 months) in adults with confirmed SARS-CoV-2 infection and PASC. Participants were classified as vaccination (receipt of an additional SARS-CoV-2 vaccine dose between visits) or no vaccination. Primary outcomes were fatigue (Fatigue Assessment Scale) and exercise capacity (6-minute walk distance). Propensity scores matching (1:1 nearest-neighbor, ATT; caliper 0.2 SD) was performed using logistic regression. Group differences were assessed using t-tests/χ2 tests with Benjamini-Hochberg adjustment. Longitudinal changes were analyzed using linear mixed-effects models. Of 193 eligible patients, 174 were analyzed, 148 remained after matching (74 per group). No significant differences between the groups were observed at baseline or follow-up after adjustment for multiple comparisons. Both groups improved over time, with no statistically significant difference in fatigue or exercise capacity. Fatigue and functional performance improved over time regardless of vaccination status. We found no statistically significant association between mRNA SARS-CoV-2 vaccination and worsening symptoms or impaired recovery, although smaller effects cannot be excluded. 2026-09-18T07:00:02Z Dataset Dataset 10.6084/m9.figshare.33921656.v1 https://figshare.com/articles/dataset/Association_of_mRNA_SARS-CoV-2_vaccination_with_fatigue_and_functional_recovery_in_patients_with_post-acute_sequelae_of_COVID-19_PASC_/33921656 CC BY 4.0