2026-10-14T10:21:01Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33920611 2026-09-18T05:39:49Z category_37 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Visible-light-induced trifluoroacetylation reaction of electron-deficient nitrogen heterocycles.pdf Yanshu Li (591663) Jiangzhen An (9681294) Qiuren Wei (7119242) Huachun Yang (25070278) Xi Li (19208) Kai Sun (140584) Zhongyan Cao (18723116) Xiaolan Chen (323944) Lingbo Qu (699449) Bing Yu (237109) Organic Chemistry azauracils minisci-type reaction nitrogen heterocycles photocatalysis trifluoroacetylation <p>The direct C–H trifluoroacetylation of electron-deficient nitrogen heterocycles remains a longstanding challenge with conventional reagents, owing to the inherent instability of the trifluoroacetyl radical and its polarity mismatch with electron-deficient substrates. Here, a novel method for the trifluoroacetylation of electron-deficient nitrogen heterocycles has been developed; under visible-light irradiation, the protocol operates without the need for cumbersome substrate pre-functionalization, expensive catalysts, transition metals, or additional additives. This approach enables the efficient trifluoroacetylation of diverse substrates, including pyridine, quinoline, quinoxalinone, chromone, and azauracil, and exhibits broad functional group tolerance and versatility, rendering it highly suitable for the late-stage functionalization of various bioactive molecules. By overcoming the polarity-mismatch limitation, this strategy addresses the longstanding challenge of direct C–H trifluoroacetylation of electron-deficient nitrogen heterocycles and aligns with the principles of sustainable chemistry.</p> 2026-09-18T05:39:49Z Dataset Dataset 10.3389/fchem.2026.1957846.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Visible-light-induced_trifluoroacetylation_reaction_of_electron-deficient_nitrogen_heterocycles_pdf/33920611 CC BY 4.0