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oai:figshare.com:article/33920569 2026-09-18T05:39:07Z category_393 portal_316 item_type_3 month_year_09_2026

Supplementary file 1_Global burden of diarrheal diseases attributable to 13 pathogens in children under five: a comprehensive analysis from GBD 2021.docx Xue Li (285380) Liping Guo (596697) Yongyan Chen (86296) Hanjuan Zhang (20854817) Foetal Development and Medicine burden of diarrheal disease children mortality neonates pathogens Introduction<p>Diarrheal diseases remain a major cause of death and disability among children under five, especially in low- and middle-income countries (LMICs).</p>Methods<p>Using Global Burden of Disease Study 2021 (GBD 2021) data, we assessed mortality and disability-adjusted life years (DALYs) attributable to 13 diarrheal pathogens across 204 countries from 1990 to 2021. Analyses included age-stratified burden estimation, temporal trend analysis using estimated annual percentage change (EAPC), and frontier analysis with the Socio-demographic Index (SDI).</p>Results<p>From 1990 to 2021, global diarrheal deaths declined from 2.43 million to 0.56 million, and DALYs from 218.14 million (95% UI: 131.58–335.90 million) to 50.63 million (95% UI: 28.77–82.70 million). Rotavirus and Shigella remained leading causes of mortality, while Clostridioides difficile was the only pathogen with a positive EAPC, indicating an increasing burden. Considerable regional and national disparities persisted, with the highest mortality in Chad (842.44 per 100,000) and the lowest in Andorra (0.05 per 100,000).</p>Discussion<p>These findings underscore the need for pathogen-specific, regionally targeted interventions to further reduce child mortality and disability.</p> 2026-09-18T05:39:07Z Dataset Dataset 10.3389/fped.2026.1846669.s001 https://figshare.com/articles/dataset/Supplementary_file_1_Global_burden_of_diarrheal_diseases_attributable_to_13_pathogens_in_children_under_five_a_comprehensive_analysis_from_GBD_2021_docx/33920569 CC BY 4.0