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oai:figshare.com:article/33920077 2026-09-18T04:42:22Z category_140 portal_316 item_type_3 month_year_09_2026

Table 5_Ischemic heart disease mortality trends and disparities in US adults from 1999 to 2023: a CDC WONDER analysis.xlsx Jia Li (160557) Bolin Wang (11301172) Xuezhen Xuan (12965618) Fan Zhang (46132) Sichong Qian (18096583) Haiyang Li (1557451) Cardiology AAMR CDC WONDER COVID-19 pandemic IHD the United States Background<p>Ischemic heart disease (IHD) remains a leading cause of mortality in the United States, yet it remains unclear whether postpandemic recovery patterns differ across population subgroups.</p>Methods<p>Using CDC WONDER data (1999–2023), we analyzed IHD deaths among US adults aged ≥25 years. Age-adjusted mortality rates (AAMRs) were stratified by sex, race/ethnicity, urbanization, and region; crude mortality rates (CMRs) by age. Urban–rural analyses were restricted to 1999–2020. Joinpoint regression estimated temporal trends, and tests of parallelism assessed between-group differences.</p>Results<p>Among 10,200,362 IHD deaths, overall AAMRs declined from 300.8 to 127.07 per 100,000 (average annual percent change, AAPC = −3.51; p < 0.001), with the fastest decline during 2021–2023 (APC = −5.59). Males had higher AAMRs than females (245.58 vs. 138.69; p < 0.001). Non-Hispanic (NH) Black individuals had the highest AAMR (217.58). The steepest age-specific CMR decline occurred at 75–84 years (AAPC = −4.04). Metropolitan areas had lower AAMRs than non-metropolitan areas (189.07 vs. 212.60; p < 0.001). Pairwise tests confirmed significant trend differences across most subgroups (all p < 0.05), except NH Other vs. NH White (p = 0.396).</p>Conclusions<p>Despite sustained IHD mortality declines, significant disparities persist across demographic and geographic subgroups, supporting targeted prevention for high-risk populations.</p> 2026-09-18T04:42:22Z Dataset Dataset 10.3389/fcvm.2026.1883973 https://figshare.com/articles/dataset/Table_5_Ischemic_heart_disease_mortality_trends_and_disparities_in_US_adults_from_1999_to_2023_a_CDC_WONDER_analysis_xlsx/33920077 CC BY 4.0