2026-10-13T05:14:20Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33919987 2026-09-18T04:37:05Z category_19 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Microplastic exposure is associated with enhanced PI3K-Akt signaling in DSS-induced colitis: integrated bioinformatics analyses and in vivo validation.pdf Lisha Lu (12507625) Yuanming Yang (12471807) Shunyong He (25069687) Shaogang Huang (11187195) Yulong Li (748754) Pharmacology bioinformatics GMFA network microplastics molecular docking toxicology ulcerative colitis Background<p>Microplastics (MPs) are widely distributed in the environment and may aggravate ulcerative colitis (UC), but the underlying molecular mechanisms remain unclear.</p>Methods<p>We integrated network toxicology, RNA-seq-based differential expression analysis, molecular docking, GeneMANIA-based functional association analysis, and experimental validation in a murine DSS-induced colitis model.</p>Results<p>We identified 421 MP-related and 6,452 UC-related targets, including 265 overlapping targets. PIK3CD, PIK3CA, SRC, PTPN11, and EGFR were prioritized as hub targets with stable ligand binding. Enrichment analyses implicated the PI3K-Akt, JAK-STAT, T-cell receptor, and HIF-1 signaling pathways. In vivo experiments showed that MP exposure increased the colonic abundance of these five proteins and enhanced p-PI3K and p-AKT signals in DSS-induced colitis.</p>Conclusion<p>MP exposure is associated with enhanced PI3K-Akt signaling in experimental colitis. These findings provide preliminary biological support for the PI3K-Akt pathway as a potentially relevant mechanism linking MP exposure to UC aggravation.</p> 2026-09-18T04:37:05Z Dataset Dataset 10.3389/fphar.2026.1875549 https://figshare.com/articles/dataset/Data_Sheet_1_Microplastic_exposure_is_associated_with_enhanced_PI3K-Akt_signaling_in_DSS-induced_colitis_integrated_bioinformatics_analyses_and_in_vivo_validation_pdf/33919987 CC BY 4.0