2026-10-12T09:11:16Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33900202 2026-09-17T15:58:28Z category_374 portal_316 item_type_3 month_year_09_2026

Supplementary file 2_Nutritional ultrasound cut off for predicting complications and mortality in lung cancer patients: a multicenter longitudinal study from the VALONC project.docx Jose M. Romero-Márquez (24596253) María González-Pacheco (25033132) Rocío Fernández-Jiménez (17437566) Alba Carmona-Llanos (25033135) María Teresa Zarco-Martín (18006841) Pablo Rodríguez de Vera-Gómez (25033138) Fernanda Mucarzel-Suarez-Arana (25033141) Silvia García-Rey (22654979) Ana Sanz-Sanz (25033144) María Isabel Rebollo Pérez (25033147) María Luisa Fernandez-Soto (25033150) Vicente Mustieles (8955020) Araceli Muñoz-Garach (5164697) José Manuel García-Almeida (20380101) Clinical and Sports Nutrition dynapenia GLIM criteria malnutrition morphofunctional assessment nutritional ultrasound rectus femoris sarcopenia Introduction<p>Lung cancer remains a leading cause of cancer-related mortality, often exacerbated by malnutrition and muscle depletion that traditional weight-centric metrics may fail to identify. This study assessed the clinical and prognostic relevance of rectus femoris (RF) ultrasound as a practical bedside tool for evaluating muscle-related parameters and clinical outcomes.</p>Methods<p>This multicenter longitudinal study involved 374 patients (114 females, 260 males) across 10 Spanish hospitals. Researchers performed ultrasonographic assessments of the RF, measuring cross-sectional area (RF-CSA), thickness (Y-axis), and circumference, alongside GLIM malnutrition criteria and PG-SGA. Statistical analyses included Random Forest algorithms, ROC curves, and Cox regression models adjusted for age, BMI, ECOG performance status, cancer type, and cancer stage to determine sex-specific associations with clinical outcomes.</p>Results<p>Significant sexual dimorphism was observed; men exhibited larger muscle parameters, while women had higher subcutaneous fat. RF-CSA and RF-Y-axis showed the highest discriminative performance for GLIM-defined malnutrition, with AUCs of 0.706 and 0.713 in men and 0.814 and 0.804 in women, respectively. The corresponding RF-CSA cut-offs were 3.88 cm² in men and 2.78 cm² in women, whereas RF-Y-axis cut-offs were 1.09 cm in men and 0.95 cm in women. In men, RF-Y-axis was significantly associated with all-cause mortality (HR = 0.32, 95% CI: 0.15–0.71), whereas RF-CSA, RF-CIR, and RF-X-axis were associated with clinical complications. No significant associations with mortality or complications were observed in women. A moderate agreement was observed between GLIM and PG-SGA (weighted κ = 0.51), suggesting that these criteria capture overlapping but not identical dimensions of malnutrition.</p>Discussion<p>Rectus femoris ultrasound may provide objective, sex-specific clinical information that complements the GLIM framework and traditional anthropometric assessments. By identifying clinically relevant muscle waste, this bedside tool allows for the early detection of high-risk patients, potentially directing timely nutritional and rehabilitative interventions to improve survival and treatment tolerance in lung cancer.</p> 2026-09-17T15:58:28Z Dataset Dataset 10.3389/fnut.2026.1876352.s001 https://figshare.com/articles/dataset/Supplementary_file_2_Nutritional_ultrasound_cut_off_for_predicting_complications_and_mortality_in_lung_cancer_patients_a_multicenter_longitudinal_study_from_the_VALONC_project_docx/33900202 CC BY 4.0