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oai:figshare.com:article/33882906 2026-09-17T10:06:56Z category_1 category_4 category_7 category_873 category_61 category_64 portal_63 item_type_3 month_year_09_2026

Mechanochemical Access to 2,4-Diaroyl-5-aminothiazoles from β‑Ketothioamides at Room Temperature Nimisha Gupta (9590520) Ganesh Kumar (1342359) Malkeet Singh (8837471) Maya Shankar Singh (1725268) Biophysics Biochemistry Medicine Chemical Sciences not elsewhere classified Developmental Biology Cancer hrms studies validated free mild conditions easily accessible substrates developed utilizing sio broad substrate scope aminothiazoles via formal 3 -( hydroxyimino hitherto unreported 2 β ‑ ketothioamides room temperature proposed mechanism mechanochemical approach mechanochemical access control experiments bond formation A mechanochemical approach to hitherto unreported 2,4-diaroyl-5-aminothiazoles via formal [3 + 2] heteroannulation of β-ketothioamides with 3-(hydroxyimino) chromane-2,4-diones has been developed utilizing SiO₂-assisted hand grinding in a mortar with pestle at room temperature within 10 min. The reaction proceeds via C(sp²)–S bond formation/dehydrative intramolecular cyclization cascade. This strategy is distinguished by safe and easily accessible substrates, metal-free mild conditions, broad substrate scope, and wide functional group compatibility. Control experiments, DFT, and HRMS studies validated the proposed mechanism. 2026-09-17T00:00:00Z Dataset Dataset 10.1021/acs.joc.6c01615.s001 https://figshare.com/articles/dataset/Mechanochemical_Access_to_2_4-Diaroyl-5-aminothiazoles_from_Ketothioamides_at_Room_Temperature/33882906 CC BY-NC 4.0