2026-10-13T10:01:44Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33872563 2026-09-26T08:37:58Z category_24610 category_24205 category_24811 item_type_3 month_year_09_2026

Epithelial programmes of checkpoint inhibitor colitis recur across patient cohorts and respond nonuniformly to TNFSF12 in human intestinal organoids Xiaohe Zhou (7518143) Xiaotong Sun (25002509) Bohan Lin (25002514) Huabiao Chen (522980) Chengdong Wu (24694289) Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies) Translational and applied bioinformatics Oncology and carcinogenesis not elsewhere classified immune checkpoint inhibitors (ICBs) immune-related adverse events < immunotherapy checkpoint inhibitor colitis checkpoint myocarditis transcriptomics bioinformatics <p dir="ltr">This dataset provides the source data and supporting analysis files for the manuscript entitled “Multimodal human data distinguish shared inflammatory pressure from context-dependent receiver-cell remodelling in checkpoint blockade toxicity.”</p><p dir="ltr">The deposited files contain complete source tables (Source_001–Source_079), figure source data, provenance and record information, analysis summaries, the selection-history appendix, cohort-specific clinical results and plots, and supporting documentation used to reproduce the reported analyses.</p><p dir="ltr">The associated study integrates publicly available human datasets spanning immune checkpoint inhibitor-associated myocarditis and colitis, epithelial transcriptomic programmes, T-cell receptor repertoires, spatial measurements, intestinal-organoid perturbation experiments, and tumour immunotherapy cohorts.</p><p dir="ltr">This repository contains derived and processed analysis outputs generated for the study. Original third-party public datasets are not redistributed here and remain available from their respective repositories and accession numbers as described in the manuscript. Analysis and figure-generation code is available separately through the ICI_irAE_Code GitHub repository.</p><p dir="ltr">The deposited source data support the results, figures and supplementary analyses reported in the manuscript.</p> 2026-09-26T08:37:58Z Dataset Dataset 10.6084/m9.figshare.33872563.v3 https://figshare.com/articles/dataset/_b_Source_data_for_Multimodal_human_data_distinguish_shared_inflammatory_pressure_from_context-dependent_receiver-cell_remodelling_in_checkpoint_blockade_toxicity_b_/33872563 CC BY 4.0