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oai:figshare.com:article/33872152 2026-09-17T05:54:50Z category_374 portal_316 item_type_3 month_year_09_2026

Supplementary file 1_Associations of body fat percentage-based obesity with depression and comorbidity-related gut microbiota features in college students.pdf Yingli Xu (20909971) Zhenchi Niu (25002259) Long Zhou (103944) Wenqing Ding (3507503) Jing Li (10611) Clinical and Sports Nutrition body fat percentage college students depression gut microbiota obesity Introduction<p>The association between body fat percentage (BFP)-defined obesity and depression in college students remains unclear, and gut microbiota alterations in this comorbid condition have not been fully characterized.</p>Methods<p>A total of 906 college students were recruited to examine the prevalence of comorbid obesity and depression and the association between body fat percentage-defined obesity and depression. Logistic regression was used for association analysis. Subsequently, 104 participants balanced for age and sex distributions across groups were selected and divided into four groups: obese with depression (G1), non-obese with depression (G2), obese without depression (G3), and non-obese without depression (G4). Fecal samples were analyzed by 16S rRNA gene sequencing.</p>Results<p>The prevalence of comorbid obesity and depression was 9.71%. BFP-defined obesity was significantly associated with depression after adjustment for covariates (OR = 1.62, 95% CI: 1.10–2.38). Gut microbiota analysis showed no significant differences in α-diversity among groups, whereas β-diversity differed significantly between the G1 and G4 (P < 0.05). Descriptive taxonomic profiles suggested differences in the relative abundances of several genera (e.g., decreased Akkermansia, increased Fusobacterium and Collinsella in G1). PICRUSt- based functional prediction suggested differences in inferred microbial metabolic pathways between G1 and other groups, including higher predicted lipopolysaccharide biosynthesis pathway abundance than in G2 and G4.</p>Discussion<p>BFP-defined obesity was associated with depression in college students. The microbiome findings were exploratory and suggest that co-occurring obesity and depression may be associated with differences in gut microbial composition and predicted functional potential. Larger longitudinal studies with direct functional and inflammatory measurements are needed.</p> 2026-09-17T05:54:50Z Dataset Dataset 10.3389/fnut.2026.1906822.s001 https://figshare.com/articles/dataset/Supplementary_file_1_Associations_of_body_fat_percentage-based_obesity_with_depression_and_comorbidity-related_gut_microbiota_features_in_college_students_pdf/33872152 CC BY 4.0