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oai:figshare.com:article/33871705 2026-09-17T05:30:36Z category_8 portal_316 item_type_3 month_year_09_2026

Table 1_Dietary supplementation with Lactobacillus plantarum and Bacillus velezensis improves growth performance, antioxidant capacity, immunity and intestinal microbiota in growing-finishing pigs.docx Zijing Zhang (2897816) Zihe Li (5619026) Yingmei Zhang (22388) Xinyu Wu (187974) Xiaojia Wu (12217937) Xi Chen (35903) Liang Peng (142254) Qinghua Liu (64392) Changchuan Ye (11270642) Microbiology antioxidant Bacillus velezensis growing pigs immunity intestinal microbiota Lactobacillus plantarum probiotics Introduction<p>Compound probiotics have gained increasing recognition for their ability to improve growth performance and animal health in animal production. This study evaluated the effects of dietary supplementation with Lactobacillus plantarum QZF (10¹¹ CFU/d), Bacillus velezensis BD01 (10¹² CFU/d) or their combination on growth performance, serum biochemistry, antioxidant capacity, immunity and gut microbiota in growing pigs.</p>Methods<p>A total of 160 growing Landrace × Yorkshire gilts were randomly assigned to four treatment groups: CON (basal diet), SPL (basal diet supplemented with L. plantarum fermentation broth), SPB (basal diet supplemented with B. velezensis fermentation broth), and DP (basal diet supplemented with both strains fermentation broth). Each group consisted of 40 pigs (8 replicates of 5 pigs), and the experiment lasted 47 days.</p>Results<p>The SPB and DP groups showed significantly higher average daily gain and serum total protein than CON group, attributed to the main effect of B. velezensis (p_(B) < 0.01). The SPL, SPB, and DP groups showed significant increases in serum total cholesterol, free fatty acids and urea nitrogen (p_(L) < 0.01 for TC and FFA; p_(L) < 0.01, p_(B) < 0.01, and p_{(L × B)} < 0.01 for BUN). Serum antioxidant enzyme activities (SOD, CAT, and GSH-Px) were significantly affected by both the main effect of L. plantarum and the main effect of B. velezensis, with no significant L × B interaction. In contrast, total antioxidant capacity (T-AOC) was significantly affected only by the main effect of B. velezensis, whereas neither the main effect of L. plantarum or the L × B interaction was significant. For immune parameters, ALB and IgG were increased by B. velezensis (p_(B) < 0.05), while IgM and IgA were elevated by L. plantarum (p_(L) < 0.05). No interaction was detected for these parameters. Microbiota analysis revealed increased alpha diversity (ACE and Chao1) and altered microbial composition, with B. velezensis increasing Proteobacteria and the compound probiotic enriching Actinobacteriota and Lactobacillales.</p>Discussion<p>In conclusion, dietary probiotics, especially the multi strain combination, positively influenced growth performance, immune function, and antioxidant capacity in growing pigs, representing a promising nutritional strategy for swine production.</p> 2026-09-17T05:30:36Z Dataset Dataset 10.3389/fmicb.2026.1913467.s001 https://figshare.com/articles/dataset/Table_1_Dietary_supplementation_with_Lactobacillus_plantarum_and_Bacillus_velezensis_improves_growth_performance_antioxidant_capacity_immunity_and_intestinal_microbiota_in_growing-finishing_pigs_docx/33871705 CC BY 4.0