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oai:figshare.com:article/33870970 2026-09-17T04:46:04Z category_374 portal_316 item_type_3 month_year_09_2026

Table 1_Impact of incremental peritoneal dialysis on long-term nutritional trajectories in end-stage kidney disease: a longitudinal cohort study.docx Yaohua Hu (500185) Xiaohua Zhuang (11890694) Jingzhu Zhai (25001692) Xinyu Gao (5327597) Wenpeng Cui (9282017) Clinical and Sports Nutrition end-stage kidney disease (ESKD) incremental peritoneal dialysis inverse probability weighting nutritional trajectories prognostic nutritional index Background<p>Incremental peritoneal dialysis (IPD) seeks to reduce the immediate treatment burden by utilizing residual kidney function. However, its long-term effects on nutritional status remain unclear. This study investigated how an initial IPD strategy influences the longitudinal trajectories of the prognostic nutritional index (PNI) in patients with end-stage kidney disease (ESKD).</p>Methods<p>This retrospective study included patients who received peritoneal dialysis (PD) at the Second Hospital of Jilin University between January 2016 and July 2024. We employed linear mixed-effects models to analyze population-level trends in PNI. Group-based trajectory modeling (GBTM) was utilized to identify patterns of PNI evolution, while multivariable Cox models assessed the relationship between these patterns and all-cause mortality. Additionally, multivariable logistic regression, which included multiple imputation and entropy balancing-derived inverse probability weights (IPW), was used to explore the independent association between the type of dialysis and trajectory membership.</p>Results<p>A total of 311 patients who initiated PD between 2016 and 2024 were included, of whom 230 received full-dose PD and 81 received IPD. Throughout the follow-up period, 80.25% of patients on IPD were transitioned to full-dose PD at a median of 10 months. Mixed-effects modeling indicated no significant differences in PNI levels or rates of decline between the two modalities (time-by-modality interaction P = 0.378). GBTM revealed three distinct PNI trajectories: low, moderate, and high. The high-level trajectory was associated with a significantly reduced risk of mortality compared to the low-level group (fully adjusted HR = 0.17, P < 0.001). However, in IPW-adjusted models, the initial dialysis modality did not show an independent association with any specific PNI trajectory. These findings remained consistent across multiple sensitivity analyses.</p>Conclusions<p>When accompanied by dynamic prescription adjustments, IPD sustains mid- to long-term nutritional trajectories that are comparable to those achieved with full-dose PD.</p> 2026-09-17T04:46:04Z Dataset Dataset 10.3389/fnut.2026.1885616.s001 https://figshare.com/articles/dataset/Table_1_Impact_of_incremental_peritoneal_dialysis_on_long-term_nutritional_trajectories_in_end-stage_kidney_disease_a_longitudinal_cohort_study_docx/33870970 CC BY 4.0