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oai:figshare.com:article/33870514 2026-09-17T04:26:37Z category_374 portal_316 item_type_3 month_year_09_2026

Table 2_Association between vitamin D supplementation and mortality in elderly critically ill patients: a retrospective propensity score–matched cohort study.doc Zhongmin Tian (5487578) Yanjun Liu (367302) Yijing Zhou (1939489) Lu Wang (45927) Yeqiong He (25001188) Lei Zuo (5044436) Jixin Chen (1327974) Fan Wang (135182) Haitao Liu (89647) Clinical and Sports Nutrition elderly patients intensive care mortality prognosis vitamin D supplementation Purpose<p>Vitamin D deficiency is highly prevalent among elderly critically ill patients and has been associated with adverse outcomes. However, evidence regarding the prognostic benefit of vitamin D supplementation in this population remains limited. This study aimed to investigate the association between vitamin D supplementation and 28-day mortality in elderly patients admitted to the intensive care unit (ICU).</p>Methods<p>This retrospective cohort study utilized data from the medical information mart for intensive care IV (MIMIC-IV) database, including patients aged ≥65 years. Propensity score matching (PSM) balanced baseline characteristics between patients who received vitamin D within 48 h of ICU admission and those who did not. Cox proportional hazards models estimated hazard ratios (HRs) with 95% confidence intervals (CIs), and E-value analysis assessed unmeasured confounding.</p>Results<p>After PSM, 8,111 patients were included, with 1,338 (16.5%) deaths within 28 days. The 28-day mortality rate was significantly lower in the vitamin D supplementation group than in the non-supplemented group (14.5% vs. 17.0%, P = 0.017). Multivariable Cox regression demonstrated that vitamin D supplementation was independently associated with lower 28-day mortality (HR = 0.819, 95% CI: 0.710–0.946, P = 0.006). Subgroup analyses revealed more pronounced associations in females and patients without certain chronic comorbidities.</p>Conclusion<p>Vitamin D supplementation within 48 h of ICU admission was significantly associated with reduced 28-day mortality in elderly critically ill patients. Further prospective interventional studies are required to verify causal relationships and optimize administration regimens.</p> 2026-09-17T04:26:37Z Dataset Dataset 10.3389/fnut.2026.1932001.s001 https://figshare.com/articles/dataset/Table_2_Association_between_vitamin_D_supplementation_and_mortality_in_elderly_critically_ill_patients_a_retrospective_propensity_score_matched_cohort_study_doc/33870514 CC BY 4.0