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          <dc:title>&lt;p&gt;Search strategy for MEDLINE.&lt;/p&gt;</dc:title>
          <dc:creator>Roberta Z. J. McGuinness (24998898)</dc:creator>
          <dc:creator>Nichole Fairbrother (10839876)</dc:creator>
          <dc:creator>Fiona L. Challacombe (24998901)</dc:creator>
          <dc:subject>Medicine</dc:subject>
          <dc:subject>Biotechnology</dc:subject>
          <dc:subject>Sociology</dc:subject>
          <dc:subject>Cancer</dc:subject>
          <dc:subject>Science Policy</dc:subject>
          <dc:subject>Infectious Diseases</dc:subject>
          <dc:subject>two independent reviewers</dc:subject>
          <dc:subject>text available online</dc:subject>
          <dc:subject>synthesise existing research</dc:subject>
          <dc:subject>present protocol describes</dc:subject>
          <dc:subject>preferred reporting items</dc:subject>
          <dc:subject>inform clinical services</dc:subject>
          <dc:subject>24 months post</dc:subject>
          <dc:subject>small sample size</dc:subject>
          <dc:subject>review protocol aims</dc:subject>
          <dc:subject>systematic review investigating</dc:subject>
          <dc:subject>perinatal period represents</dc:subject>
          <dc:subject>aaards assessed using</dc:subject>
          <dc:subject>selected sample</dc:subject>
          <dc:subject>assessed using</dc:subject>
          <dc:subject>systematic review</dc:subject>
          <dc:subject>perinatal period</dc:subject>
          <dc:subject>systematic reviews</dc:subject>
          <dc:subject>perinatal aaards</dc:subject>
          <dc:subject>xlink "&gt;</dc:subject>
          <dc:subject>validated measure</dc:subject>
          <dc:subject>third reviewer</dc:subject>
          <dc:subject>search terms</dc:subject>
          <dc:subject>related disorders</dc:subject>
          <dc:subject>registration code</dc:subject>
          <dc:subject>previous reviews</dc:subject>
          <dc:subject>natural course</dc:subject>
          <dc:subject>narratively synthesised</dc:subject>
          <dc:subject>modified version</dc:subject>
          <dc:subject>inclusion criteria</dc:subject>
          <dc:subject>following databases</dc:subject>
          <dc:subject>exclusion criteria</dc:subject>
          <dc:subject>diagnostic interview</dc:subject>
          <dc:subject>could help</dc:subject>
          <dc:subject>conflicts resolved</dc:subject>
          <dc:subject>black checklist</dc:subject>
          <dc:subject>birthing people</dc:subject>
          <dc:subject>adverse outcomes</dc:subject>
          <dc:subject>aaards assessed</dc:subject>
          <dc:subject>10 ),</dc:subject>
          <dc:subject>&amp;# 8805</dc:subject>
          <dc:description>&lt;div&gt;
&lt;p&gt;Background&lt;/p&gt;&lt;p&gt;The perinatal period represents a high-risk period for anxiety, with symptoms of anxiety associated with a range of adverse outcomes for birthing people and children. Previous reviews have assessed the prevalence of anxiety during the perinatal period. However, the long-term course of perinatal anxiety remains unclear. This review protocol aims to investigate the long-term, natural course of anxiety symptoms, anxiety disorders, and anxiety-related disorders (AAARDS) among birthing people.&lt;/p&gt;
&lt;p&gt;Methods&lt;/p&gt;&lt;p&gt;A systematic review and, if appropriate, meta-analysis will be conducted according to the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Search terms will be applied to the following databases: MEDLINE, EMBASE, CINAHL, Web of Science, and PsycINFO. Inclusion criteria will be: (1) prevalence of AAARDS assessed at least once during the perinatal period and at ≥24 months post-birth, (2) AAARDS assessed using a validated measure and/or diagnostic interview, (3) full-text available online. Exclusion criteria will be: (1) grey literature, (2) qualitative, interventional, or animal studies, (3) studies with a selected sample, (4) studies with a small sample size (N &lt; 10), and (5) studies that synthesise existing research. Screening and data extraction will be conducted by two independent reviewers, with any conflicts resolved by a third reviewer. Risk of bias will be assessed using a modified version of the Downs and Black checklist. Data will be narratively synthesised, and meta-analyses will be conducted where appropriate.&lt;/p&gt;
&lt;p&gt;Discussion&lt;/p&gt;&lt;p&gt;The present protocol describes the methodology for a systematic review investigating the long-term course of perinatal AAARDS. Findings will address a gap in the literature and enhance our understanding of the natural course of perinatal anxiety, which could help to inform clinical services and resource allocation.&lt;/p&gt;
&lt;p&gt;Registration&lt;/p&gt;&lt;p&gt;This review has been registered on PROSPERO (registration code: CRD420251073221).&lt;/p&gt;&lt;/div&gt;</dc:description>
          <dc:date>2026-09-16T17:49:40Z</dc:date>
          <dc:type>Dataset</dc:type>
          <dc:type>Dataset</dc:type>
          <dc:identifier>10.1371/journal.pone.0356689.t001</dc:identifier>
          <dc:relation>https://figshare.com/articles/dataset/_p_Search_strategy_for_MEDLINE_p_/33867270</dc:relation>
          <dc:rights>CC BY 4.0</dc:rights>
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