2026-10-12T21:39:52Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33866235 2026-09-16T17:36:57Z category_1 category_4 category_7 category_8 category_13 category_19 category_873 category_734 category_931 category_64 portal_5 item_type_3 month_year_09_2026

<p>Efficacy of the GRR-predicted drugs and compounds in four breast cancer cell lines: SUM149, SUM159, MDA-MB-231, and MCF-7 (Hoechst assay).</p> Esraa A. Salim (24998673) Xiaojia Ji (17147845) Michael Tarpley (24998676) Maria S. Dixon (24998679) Weifan Zheng (2317405) John E. Scott (8883608) Kevin P. Williams (8883605) Biophysics Biochemistry Medicine Microbiology Genetics Pharmacology Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Information Systems not elsewhere classified Cancer systematic drug repurposing sum149 cells confirmed spheroid sum149 models novel therapeutic candidates limited therapeutic options key signaling proteins inflammatory breast cancer experimental approach establishes compounds previously identified systematic combination screening two computational approaches gene reversal rate experimental validation study novel synergistic combinations ibc cell lines repurposed compounds predicted experimental validation candidate compounds combination treatments success rate integrated computational computational predictions transcriptional level silico </ significantly altered seq analysis rare cancers mtor pathways inhibit growth grr showed grr ). downstream effectors aggressive type <p>Efficacy of the GRR-predicted drugs and compounds in four breast cancer cell lines: SUM149, SUM159, MDA-MB-231, and MCF-7 (Hoechst assay).</p> 2026-09-16T17:36:22Z Dataset Dataset 10.1371/journal.pone.0339543.t002 https://figshare.com/articles/dataset/_p_Efficacy_of_the_GRR-predicted_drugs_and_compounds_in_four_breast_cancer_cell_lines_SUM149_SUM159_MDA-MB-231_and_MCF-7_Hoechst_assay_p_/33866235 CC BY 4.0