2026-10-11T11:02:05Z https://api.figshare.com/v2/oai

oai:figshare.com:article/33865965 2026-09-16T17:34:12Z category_7 category_14 category_21 category_734 category_106 portal_5 item_type_3 month_year_09_2026

<p>Managing the four characteristic failure modes as two layers. A prompt constraint reduces each failure upstream, before it occurs; because constraints reduce but do not eliminate risk, a residual risk always remains, and downstream verification is designed to catch it. How much verification an output needs scales with its stakes (Section 4).</p> Thomas Sharpton (6262145) Edward W. Davis II (7460450) Alexandra Alexiev (11301879) Medicine Molecular Biology Biotechnology Biological Sciences not elsewhere classified Science Policy source repository (< separate topics rather llm architecture produces life science researchers large language models including literature synthesis effective prompt design common research tasks life science workflows risk across dimensions help researchers use div >< p practical risk framework structured framework detailed workflows responsible use immediate use writing assistance worked examples unified approach tools carefully statistical reasoning researcher expertise remarkable capabilities reference checklists particular attention paper addresses output verifiability integrated components documentation practices companion open code generation characteristic failures administrative work <p>Managing the four characteristic failure modes as two layers. A prompt constraint reduces each failure upstream, before it occurs; because constraints reduce but do not eliminate risk, a residual risk always remains, and downstream verification is designed to catch it. How much verification an output needs scales with its stakes (Section <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014776#sec004" target="_blank">4</a>).</p> 2026-09-16T17:34:00Z Dataset Dataset 10.1371/journal.pcbi.1014776.t002 https://figshare.com/articles/dataset/_p_Managing_the_four_characteristic_failure_modes_as_two_layers_A_prompt_constraint_reduces_each_failure_upstream_before_it_occurs_because_constraints_reduce_but_do_not_eliminate_risk_a_residual_risk_always_remains_and_downstream_verificati/33865965 CC BY 4.0